IgA肾病伴系膜区Ⅲ型胶原沉积2例  

IgA nephropathy with mesangial typeⅢcollagen deposition:2 cases report

作　　者：黄洁波 蔡小凡 赵仲华 张志刚 沈强 王浩[1] 吴慧娟 HUANG Jie-bo;CAI Xiao-fan;ZHAO Zhong-hua;ZHANG Zhi-gang;SHEN Qiang;WANG Hao;WU Hui-juan(Departments of Nephrology,Putuo Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China;1^(th)Department of Nephrology,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Department of Pathology,School of Basic Medical Sciences,Fudan University,Shanghai 200032,China;Department of Electron Microscope,School of Basic Medical Sciences,Fudan University,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属普陀医院肾内科,上海200062 [2]上海市中医药大学附属龙华医院肾病一科,上海200032 [3]复旦大学基础医学院病理学系,上海200032 [4]复旦大学基础医学院电子显微镜中心实验室,上海200032

出　　处：《复旦学报（医学版）》2024年第3期426-430,共5页Fudan University Journal of Medical Sciences

基　　金：上海中医药大学预算内项目(2021LK053);上海市普陀区卫生健康系统临床特色专科项目(2021tszk02);上海龙华医院爱建基金(AJ069);上海龙华医院龙医学者项目(KC2022013)。

摘　　要：型胶原(typeⅢcollagen,ColⅢ)作为间质胶原在正常肾小球内无分布,但Ⅲ型胶原肾病时大量胶原沉积于肾小球系膜区及内皮下。IgA肾病合并Ⅲ型胶原沉积极为罕见。本文报道了2例IgA肾病合并Ⅲ型胶原沉积的患者,经过免疫抑制治疗或中药汤剂治疗后,肾功能稳定且尿蛋白水平均明显下降。As interstitial collagen,typeⅢcollagen(ColⅢ)does not express in normal glomeruli.However,in ColⅢnephropathy,a large amount of ColⅢdeposit in the mesangial and subendothelial area of the glomeruli.IgA nephropathy with ColⅢdeposition was extremely rare.In this article,we reported two cases of such disease.After treating with immunosuppressive agents or traditional Chinese medicine decoction,the renal function of the two patients remained stable and the urinary protein levels reduced significantly.

关 键 词：肾小球肾炎 IGA肾病 Ⅲ型胶原(ColⅢ) 系膜区 

分 类 号：R692.31[医药卫生—泌尿科学]