2022年沈阳市某三级甲等医院细菌耐药监测结果分析  

Analysis of bacterial resistance monitoring results in a tertiary hospital in Shenyang in 2022

作　　者：郭丽洁[1] 杨书桓 李富顺[1] 陈静静[1] 王齐晖[1] 褚云卓[1] GUO Lijie;YANG Shuhuan;LI Fushun;CHEN Jingjing;WANG Qihui;CHU Yunzhuo(Department of Laboratory Medicine,The First Hospital of China Medical University,Shenyang 110001,China;School of Pharmacy,Shenyang Pharmaceutical University,Benxi 117004,China)

机构地区：[1]中国医科大学附属第一医院检验科,沈阳110001 [2]沈阳药科大学药学院,辽宁本溪117004

出　　处：《中国医科大学学报》2024年第5期458-463,共6页Journal of China Medical University

摘　　要：目的分析2022年沈阳市某三级甲等医院病原菌分布及其耐药情况,为医院制定抗菌药物应用策略提供依据。方法收集从2022年沈阳市某三级甲等医院就诊患者中分离的病原菌,按照全国临床检验操作规程的要求进行菌株鉴定及药敏试验,使用Whonet 5.6软件进行数据分析。结果2022年共分离4968株病原菌,其中前5位为大肠埃希菌、肺炎克雷伯菌、鲍曼不动杆菌、屎肠球菌和铜绿假单胞菌。大肠埃希菌和肺炎克雷伯菌对碳青霉烯药物耐药率分别为1.9%和17.7%,阴沟肠杆菌对亚胺培南和美罗培南耐药率分别为26.7%和25.0%。耐甲氧西林金黄色葡萄球菌(MRSA)分离率15.6%。万古霉素耐药屎肠球菌、利奈唑胺耐药粪肠球菌分离率分别为7.1%、11.6%。热带念珠菌对氟康唑耐药率>20%。结论该医院病原菌分布及耐药率与国内其他地区监测结果存在差异,有必要进行医院菌株的耐药监测,及时了解病原菌分布及耐药情况,为抗感染诊治提供依据。Objective To analyze pathogen distribution and drug resistance in a tertiary hospital in Shenyang in 2022 and provide evidence-based guidance for this and other hospitals to formulate antibacterial drug application strategies.Methods In 2022,bacterial isolates collected from patients in a tertiary hospital in Shenyang were identified and subjected to drug sensitivity tests based on the requirements of the national clinical laboratory operation procedures.The data were analyzed using Whonet 5.6 software.Results In total,4968 pathogenic strains were isolated from this hospital in 2022.The top five isolates were Escherichia coli,Klebsiella pneumoniae,Acinetobacter baumannii,Enterococcus faecalis,and Pseudomonas aeruginosa.The resistance rates of Escherichia coli and Klebsiella pneumoniae to carbapenems were 1.9%and 17.7%,respectively.The resistance rates of Enterobacter cloacae to imipenem and meropenem were 26.7%and 25.0%,respectively.The isolation rate of methicillin-resistant Staphylococcus aureus(MRSA)was 15.6%.The resistance rates of vancomycin-resistant Enterococcus and linezolid-resistant Enterococcus faecalis were 7.1%and 11.6%,respectively.The resistance rates of tropical yeasts to fluconazole was>20%.Conclusion The distribution and drug resistance of pathogens in this hospital differed from those in other regions of China.The drug resistance of strains in this hospital should be closely monitored to understand the distribution and drug resistance of pathogens in a timely manner and to provide guidance for the diagnosis and treatment of infections.

关 键 词：细菌耐药监测 药敏试验 碳青霉烯耐药革兰氏阴性杆菌 

分 类 号：R378[医药卫生—病原生物学]