亚胺培南治疗脓毒症致急性呼吸窘迫综合征的效果  

Therapeutic effect of imipenem on acute respiratory distress syndrome caused by

作　　者：郦弈帆 林兆奋 Li Yi-fan;Lin Zhao-fen(Department of Emergency and Critical Care Medicine,Shanghai Changzheng Hospital,Shanghai 200003,China)

机构地区：[1]上海长征医院急诊危重症医学科,上海200003

出　　处：《中国药物应用与监测》2024年第2期140-143,共4页Chinese Journal of Drug Application and Monitoring

摘　　要：目的探讨亚胺培南治疗脓毒症致急性呼吸窘迫综合征的效果。方法纳入上海长征医院急诊危重症医学科2020年1月—2023年12月收治的98例脓毒症致急性呼吸窘迫综合征患者,以随机数字表法分为对照组、观察组,对照组49例患者进行连续性血液净化治疗,观察组49例患者进行连续性血液净化与亚胺培南联合治疗,对比两组疗效、炎症指标变化、序贯器官衰竭评估(SOFA)评分以及急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分变化。结果观察组、对照组治疗总有效率分别为91.84%、77.55%,P<0.05;观察组患者治疗后的白细胞计数(WBC)、降钙素原(PCT)、C反应蛋白(CRP)分别为(8.38±2.17)×10^(9)·L^(-1)、(0.29±0.20)μg·L^(-1)、(7.22±1.97)mg·L^(-1),均低于对照组患者的(12.57±2.25)×10^(9)·L^(-1)、(0.88±0.24)μg·L^(-1)、(10.15±2.06)mg·L^(-1),P<0.05;治疗后,观察组患者的SOFA评分为(4.17±2.00)分,APACHEⅡ评分为(7.34±2.19)分,分别低于对照组患者的(7.67±2.04)分、(11.46±2.82)分,P<0.05。结论脓毒症致急性呼吸窘迫综合征患者采取亚胺培南治疗效果良好,可较好降低机体炎症水平,改善患者病情。Objective To explore the therapeutic effect of imipenem on acute respiratory distress syndrome caused by sepsis.Methods Ninety-eight patients with acute respiratory distress syndrome caused by sepsis admitted to our hospital from January 2020 to December 2023 were enrolled in this study and randomized into the control group and the observation group.Patients in the control group(n=49)received continuous blood purification,and those in the the observation one(n=49)continuous blood purification and administration of imipenem.The efficacy,changes in inflammatory indicators,Sequential Organ Failure Assessment(SOFA)scores,acute physiological scores and Chronic Health Evaluation System Ⅱ(APACHEⅡ)scores were compared between the 2 groups.Results The total effective rate of treatment in the observation group and control group was 91.84%and 77.55%,respectively(P<0.05).After treatment,the white blood cell count(WBC),procalcitonin(PCT),and C-reactive protein(CRP)in the observation group were(8.38±2.17)×10^(9)·L^(-1),(0.29±0.20)μg·L^(-1),and(7.22±1.97)mg·L^(-1),respectively,which were all lower than those of(12.57±2.25)×10^(9)·L^(-1),(0.88±0.24)μg·L^(-1)and(10.15±2.06)mg·L^(-1)in the control(P<0.05).The SOFA score in the observation group was(4.17±2.00)points and the APACHEⅡ score was(7.34±2.19)points,which were lower than those of(7.67±2.04)points and(11.4±2.82)points in the control(P<0.05).Conclusion Imipenem has good therapeutic effect on acute respiratory distress syndrome caused by sepsis because it can better reduce the body’s inflammation level and improve the patient’s condition.

关 键 词：脓毒症 急性呼吸窘迫综合征 亚胺培南 炎症 健康状况 器官衰竭 

分 类 号：R563.9[医药卫生—呼吸系统]