阿奇霉素序贯疗法联合支气管镜下保留灌注乙酰半胱氨酸、布地奈德治疗小儿难治性支原体肺炎的临床效果  

Clinical effect of azithromycin sequential therapy combined with retained perfusion of acetylcysteine and budesonide under bronchoscopy in the treatment of refractory mycoplasma pneumoniae pneumonia in children

作　　者：李香香 刘青 马杰 LI Xiangxiang;LIU Qing;MA Jie(Xi'an International Medical Center Hospital,Xi'an 710100;Qiangsen Xingtong Hospital of Xi'an Yanta,Xi'an 710061;No.215 Hospital of Shaanxi Nuclear Industry,Xianyang 712000,China)

机构地区：[1]西安国际医学中心医院,陕西西安710100 [2]西安雁塔强森星童医院,陕西西安710061 [3]陕西省核工业二一五医院,陕西咸阳712000

出　　处：《临床医学研究与实践》2024年第16期88-91,共4页Clinical Research and Practice

基　　金：咸阳市二0二0年重点研发计划项目(No.2020K02-98)。

摘　　要：目的探讨阿奇霉素序贯疗法联合支气管镜下保留灌注乙酰半胱氨酸、布地奈德治疗小儿难治性支原体肺炎(RMPP)的临床效果。方法选择2019年4月至2022年3月收治的90例RMPP患儿为研究对象,以随机数字表法将其分为对照组与观察组,各45例。对照组给予阿奇霉素序贯疗法联合支气管镜下肺泡灌洗,观察组给予阿奇霉素序贯疗法联合支气管镜下保留灌注乙酰半胱氨酸、布地奈德。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的肺泡灌洗液支原体病菌含量优于对照组(P<0.05)。治疗后,观察组的表面活性蛋白A(SP-A)、表面活性蛋白D(SP-D)水平低于对照组(P<0.05)。结论阿奇霉素序贯疗法联合支气管镜下保留灌注乙酰半胱氨酸、布地奈德治疗小儿RMPP的效果满意,可降低肺泡灌洗液支原体病菌含量与SP-A、SP-D水平,值得推广。Objective To investigate the clinical effect of azithromycin sequential therapy combined with retained perfusion of acetylcysteine and budesonide under bronchoscopy in the treatment of refractory mycoplasma pneumoniae pneumonia(RMPP)in children.Methods A total of 90 children with RMPP admitted from April 2019 to March 2022 were selected as the research objects and divided into control group and observation group by random number table method,with 45 cases in each group.The control group was given azithromycin sequential therapy combined with bronchoalveolar lavage under bronchoscopy,while the observation group was given azithromycin sequential therapy combined with retained perfusion of acetylcysteine and budesonide under bronchoscopy.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the content of mycoplasma bacteria in alveolar lavage fluid of the observation group was better than that of the control group(P<0.05).After treatment,the levels of surfactant protein A(SP-A)and surfactant protein D(SP-D)in the observation group were lower than those in the control group(P<0.05).Conclusion Azithromycin sequential therapy combined with retained perfusion of acetylcysteine and budesonide under bronchoscopy is effective in the treatment of RMPP in children,it can reduce the content of mycoplasma bacteria in alveolar lavage fluid and the levels of SP-A and SP-D,which is worthy of promotion.

关 键 词：阿奇霉素序贯疗法 支气管镜 乙酰半胱氨酸 布地奈德 小儿 难治性支原体肺炎 

分 类 号：R725.6[医药卫生—儿科]