NGF与TrkA受体在儿童膀胱过度活动症中的研究进展  

Research Progress on NGF and TrkA Receptors in Pediatric Overactive Bladder

作　　者：何萍[1] 潮敏[1] HE Ping;CHAO Min(Department of Urology,Provincial Children′s Hospital Affiliated to Anhui Medical University,Hefei 230051,China)

机构地区：[1]安徽医科大学附属省儿童医院泌尿外科,安徽合肥230051

出　　处：《中山大学学报（医学科学版）》2024年第3期331-336,共6页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：安徽省科技厅临床医学研究转化专项项目(202304295107020066)。

摘　　要：神经生长因子(NGF)因其在神经细胞的存活、生长以及分化过程中发挥重要作用而得到广泛研究。它分布于机体的各处,根据所结合受体发挥不同的病理生理作用。原肌球蛋白相关激酶A(TrkA)是其高亲和力受体,诸多研究表明NGF在与其结合后,根据其下游不同的信号转导通路而发挥不同作用。NGF与其结合后还对体内发生的其他信号转导通路有交叉影响作用。本文从不同的疾病症状对NGF与TrkA结合后的信号转导通路进行综述,从而探讨NGF/TrkA信号通路在儿童膀胱过度活动症的作用。Nerve growth factor(NGF)has been widely studied because it plays an important role in the survival,growth and differentiation of nerve cells.It is distributed throughout the body and plays different pathophysiological roles according to the combined receptors.TrkA is its high affinity receptor,and many studies have shown that NGF plays differ-ent roles according to its downstream signal transduction pathways after combining with it.After combining with NGF,it al-so has a cross-effect on other signal transduction pathways that occur in the body.This paper reviews the signal transduc-tion pathways combined with NGF and TrkA from different disease symptoms,so as to explore the role of NGF/TrkA signal pathways in children with overactive bladder.

关 键 词：神经生长因子 儿童膀胱过度活动症 原肌球蛋白相关激酶A受体 低亲和力神经营养因子p75受体 信号转导通路 

分 类 号：R726.9[医药卫生—儿科]