冠心病合并房颤的影响因素分析  

Analysis of Factors Influencing Coronary Heart Disease Combined with Atrial Fibrillation

作　　者：钱烨晟 王慧敏 黎叶飞[1] 盛臻强[1] QIAN Yesheng;WANG Huimin;LI Yefei;SHENG Zhenqiang(Department of Cardiovascular Medicine,Nantong First People's Hospital,Nantong,Jiangsu Province,226001 China)

机构地区：[1]南通市第一人民医院心血管内科,江苏南通226001

出　　处：《系统医学》2024年第7期113-116,共4页Systems Medicine

摘　　要：目的分析冠状动脉粥样硬化性心脏病(简称冠心病)合并房颤的影响因素。方法回顾性选取南通市第一人民医院于2022年5月—2023年5月收治的50例冠心病合并房颤患者的临床资料,纳入房颤组,另选取50例同期未发生房颤的冠心病患者的临床资料纳入无房颤组,记录两组血清糖基化蛋白(Glycated Albumin,GA)及白细胞介素-4(Interleukin-4,IL-4)水平,统计两组临床资料,分析冠心病患者房颤发生的危险因素。结果两组患者年龄、性别、糖尿病史、冠心病史、冠心病病程及血红蛋白(Hemoglobin,Hb)、白细胞(White blood cells,WBC)、血小板(Platelets,PLT)、谷丙转氨酶(Alanine aminotransferase,ALT)、谷草转氨酶(Aspartate transaminase,AST)、总胆固醇(Total cholesterol,TC)、三酰甘油(Triglycerides,TG)水平对比,差异无统计学意义(P均>0.05);房颤组患者GA及IL-4水平均高于无房颤组,差异有统计学意义(P均<0.05)。多因素Logistic回归分析显示:高GA水平为冠心病患者发生房颤的危险因素(OR=3.900,P<0.05)。结论冠心病合并房颤患者血清GA及IL-4水平存在异常升高情况,高GA水平为冠心病患者发生房颤的危险因素。Objective To analyze the influencing factors of atrial fibrillation in coronary atherosclerotic heart disease Methods Clinical data 50 patients with coronary heart disease combined with atrial fibrillation admitted to Nantong First People's Hospital from May 2022 to May 2023 were retrospectively selected and included in the atrial fibrillation group,and another clinical data of 50 coronary heart disease patients without atrial fibrillation during the same period were included in the non-atrial fibrillation group,serum glycated albumin(GA)and interleukin-4(IL-4)levels were recorded in both groups,and their clinical data were collected to analyze the risk factors for the occurrence of atrial fibrillation in patients with coronary heart disease.Results Comparison of age,gender,history of diabetes mellitus,history of coronary artery disease,duration of coronary artery disease,and levels of hemoglobin(Hb),white blood cells(WBC),platelets(PLT),alanine aminotransferase(ALT),albuminous aminotransferase(AST),total cholesterol(TC),and triacylglycerol(TG)in the patients of the two groups,and there were no statistically significant differences(all P>0.05).The serum GA and IL-4 levels of patients in the atrial fibrillation group were higher than those in the non-atrial fibrillation group,and the differences were statistically significant(both P<0.05).Multifactorial logistic regression analysis showed that high GA level was a risk factor for the occurrence of atrial fibrillation in patients with coronary heart disease,and the difference was statistically significant(OR=3.900,P<0.05).Conclusion Serum GA and IL-4 levels were abnormally elevated in patients with coronary heart disease combined with atrial fibrillation,and high GA level was a risk factor for the occurrence of atrial fibrillation in patients with coronary heart disease.

关 键 词：血清糖基化白蛋白 白介素-4 冠心病 房颤 

分 类 号：R541[医药卫生—心血管疾病]