肺表面活性物质联合NCPAP辅助通气对NRDS患儿症状改善时间的影响分析  

Analysis of the Effect of Pulmonary Surfactant Combined with NCPAP Assisted Ventilation on the Improvement Time of Symptoms in Children with NRDS

作　　者：李伟伟 周静 邓盛微 吴莹 桂巍 LI Weiwei;ZHOU Jing;DENG Shengwei;WU Ying;GUI Wei(Department of Pediatrics,Jingshan People's Hospital,Jingshan,Hubei Province,431800 China;Department of Otolaryngology,Jingshan People's Hospital,Jingshan,Hubei Province,431800 China;Department of Oncology,Jingshan People's Hospital,Jingshan,Hubei Province,431800 China;Department of Outpatient,Jingshan People's Hospital,Jingshan,Hubei Province,431800 China;Department of Critical Care Medicine,Jingshan People's Hospital,Jingshan,Hubei Province,431800 China)

机构地区：[1]京山市人民医院儿科,湖北京山431800 [2]京山市人民医院耳鼻喉科,湖北京山431800 [3]京山市人民医院肿瘤科,湖北京山431800 [4]京山市人民医院门诊部,湖北京山431800 [5]京山市人民医院重症医学科,湖北京山431800

出　　处：《系统医学》2024年第7期145-148,共4页Systems Medicine

摘　　要：目的分析肺表面活性物质(Pulmonary Surfactant,PS)联合经鼻持续气道正压通气(Nasal Continuous Positive Airway Pressure Ventilation,NCPAP)辅助通气对新生儿呼吸窘迫综合征(Neonatal Respiratory Distress Syndrome,NRDS)患儿症状改善时间的影响。方法回顾性选取2019年1月—2023年6月京山市人民医院收治的68例NRDS患儿的临床资料,依据治疗方式的不同分为观察组与对照组,每组34例。对照组的治疗方式为NCPAP,观察组的治疗方式为NCPAP联合PS药物。对比两组患儿动脉血气分析指标以及治疗情况。结果治疗1 d后,与对照组比较,观察组的各项动脉血气分析指标均出现更明显的改善,差异有统计学意义(P均<0.05)。观察组的症状改善时间为(1.04±0.57)d,明显比对照组短,差异有统计学意义(t=12.393,P<0.05);同时观察组的氧疗时间、通气时间、住院时间住院均优于对照组,差异有统计学意义(P均<0.05)。结论NRDS患儿采用NCPAP联合PS药物治疗有利于改善血气指标,缩短其临床症状改善时间。Objective Analyze the effect of pulmonary surfactant(PS)combined with nasal continuous positive airway pressure ventilation(NCPAP)assisted ventilation on the improvement time of symptoms in children with neonatal respiratory distress syndrome(NRDS).Methods Clinical data of 68 children with NRDS treated in Jingshan People's Hospital from January 2019 to June 2023 were retrospectively selected and were divided into observation group and control group according to different treatment methods,with 34 cases in each group.The control group was treated with NCPAP,while the observation group was treated with NCPAP combined with PS.The indexes of arterial blood gas analysis and treatment were compared between the two groups.Results After 1 d of treatment,the arterial blood gas analysis indexes of the observation group were significantly improved compared with the control group,and the differences were statistically significant(all P<0.05).Symptom improvement time of observation group was(1.04±0.57)d,which was significantly less than that of control group,and the difference was statistically significant(t=12.393,P<0.05).At the same time,the oxygen therapy time,ventilation time and hospitalization time of the observation group were shorter than those of the control group,and the differences were statistically significant(all P<0.05).Conclusion Treatment with NCPAP combined with PS in children with NRDS can improve blood gas index and shorten the improvement time of clinical symptoms.

关 键 词：新生儿呼吸窘迫综合征 肺表面活性物质 经鼻持续气道正压通气 症状改善时间 

分 类 号：R72[医药卫生—儿科]