戊酸雌二醇联合米非司酮及米索前列醇治疗稽留流产的疗效  

Efficacy of Estradiol Valerate Combined with Mifepristone and Misoprostol in the Treatment of Missed Abortion

作　　者：李莉 赵静容 付颖 LI Li;ZHAO Jingrong;FU Ying(Department of Gynecology,Zunyi Tongzi County Hospital of Traditional Chinese Medicine,Tongzi,Guizhou Province,563200 China)

机构地区：[1]贵州省遵义市桐梓县中医医院妇科,贵州桐梓563200

出　　处：《系统医学》2024年第7期168-170,182,共4页Systems Medicine

摘　　要：目的研究稽留流产治疗中应用戊酸雌二醇+米非司酮+米索前列醇的疗效。方法选取贵州省遵义市桐梓县中医医院妇科于2021年6月—2023年6月确诊为稽留流产的40例患者为研究对象,通过抽签方式将其分为比照组(20例,米非司酮+米索前列醇)与疗效组(20例,戊酸雌二醇+米非司酮+米索前列醇),比较两组清宫术开展情况、流产率、宫颈扩张情况、人工流产综合征发生情况。结果疗效组清宫术时间(5.84±0.16)min、术中出血量(60.13±2.35)mL,优于比照组清宫术时间(8.32±0.31)min、术中出血量(93.12±4.12)mL,差异有统计学意义(t=31.792、31.105,P均<0.05);疗效组完全流产率100.00%,优于比照组完全流产率80.00%,差异有统计学意义(χ^(2)=4.444,P<0.05);疗效组宫口开大程度(2.13±0.14)分、宫颈管消退程度(2.01±0.12)分,优于比照组宫口开大程度(1.40±0.16)分、宫颈管消退程度(1.65±0.21)分,差异有统计学意义(t=15.355、6.656,P均<0.05);疗效组人工流产综合征发生率为0,优于比照组的20.00%,差异有统计学意义(χ^(2)=4.444,P<0.05)。结论稽留流产治疗过程中应用戊酸雌二醇+米非司酮+米索前列醇可以提升宫颈扩张效果,有利于清宫术开展,提高流产成功率,降低人工流产风险。Objective To study the efficacy of application of estradiol valerate+mifepristone+misoprostol in the treatment of missed abortion.Methods A total of 40 patients diagnosed with missed abortion from the Department of Gynecology,Zunyi Tongzi County Hospital of Traditional Chinese Medicine Guizhou Province,from June 2021 to June 2023 were selected as the study objects,and divided into a comparison group(20 cases,mifepristone+misoprostol)and an efficacy group(20 cases,estradiol valerate+mifepristone+misoprostol)by drawing lots.The development of purging,abortion rate,cervical dilatation,and the occurrence of abortion syndrome of two groups were compared.Results The time of purging was(5.84±0.16)min,intraoperative bleeding was(60.13±2.35)mL in the efficacy group,better than(8.32±0.31)min,(93.12±4.12)mL in the comparison group,and the differences were statistically significant(t=31.792,31.105,both P<0.05).Complete abortion rate was 100.00% in the efficacy group and better than 80.00% in the comparison group,and the difference was statistically significant(χ^(2)=4.444,P<0.05).Degree of uterine opening was(2.13±0.14)points,cervical canal regression was(2.01±0.12)points in the efficacy group,better than(1.40±0.16)points,(1.65±0.21)points in the comparison group,and the differences were statistically significant(t=15.355,6.656,both P<0.05).The incidence of abortion syndrome in the efficacy group was 0,better than the comparison group of 20.00%,and the difference was statistically significant(χ^(2)=4.444,P<0.05).Conclusion The application of estradiol valerate+mifepristone+misoprostol during the treatment of missed abortion can enhance the effect of cervical dilatation,which is conducive to the development of purging,improve the success rate of abortion and reduce the risk of abortion.

关 键 词：稽留流产 戊酸雌二醇 米非司酮 生活健康指数 米索前列醇 

分 类 号：R714[医药卫生—妇产科学]