高海拔地区H型高血压患者血管内皮功能与氧化应激的研究进展  

Research Progress on Vascular Endothelial Function and Oxidative Stress in Patients with H-type Hypertension at High Altitudes

作　　者：张柠 樊世明[2] ZHANG Ning;FAN Shiming(Graduate School of Qinghai University,Xining 810000,China;Affiliated Hospital of Qinghai University,Xining 810000,China)

机构地区：[1]青海大学研究生院,青海省西宁市810000 [2]青海大学附属医院,青海省西宁市810000

出　　处：《中国全科医学》2024年第27期3435-3439,共5页Chinese General Practice

摘　　要：高海拔地区低压、低氧环境致人体内代谢水平发生一系列变化,其特殊环境使体内氧化应激水平、同型半胱氨酸水平升高,从而损伤血管内皮细胞,高同型半胱氨酸血症会加剧氧化应激,进一步加重对血管内皮的损伤,加速高血压的发生、发展。在传统降压药治疗的基础上联合使用抗氧化药物可为高海拔地区H型高血压的治疗提供新方向。本文主要就高海拔地区H型高血压患者血管内皮功能与氧化应激的关系进行综述,探索其发病机制及可能的治疗方法。The low-pressure and low-oxygen environment at high altitude causes a series of changes in the metabolic level in the human body.The high altitude environment increases the level of oxidative stress and homocysteine in the body,which damages vascular endothelial cells.Hyperhomocysteinemia exacerbates oxidative stress,further aggravates the damage to the vascular endothelium,and accelerates the occurrence and development of hypertension.The combination of antioxidant drugs on the basis of traditional antihypertensive drug treatment provides a new direction for the treatment of H-type hypertension in high-altitude areas.This article reviews the relationship between vascular endothelial function and oxidative stress in patients with H-type hypertension in high-altitude areas,and explores its pathogenesis and possible treatments.

关 键 词：高血压 H型高血压 高同型半胱氨酸血症 血管内皮细胞 

分 类 号：R544.1[医药卫生—心血管疾病]