基于癌毒病机理论探讨连接蛋白在肿瘤微环境中作用  

Discussion on the Role of Connexin in Tumor Microenvironment based on the Theory of Cancer Toxin Pathogenesis

作　　者：叶茜文 邹玺[1,3] YE Qianwen;ZOU Xi(Affiliated Hospital of Nanjing University of Chinese Medicine,Jiangsu Nanjing 210029,China;The First Clinical School of Nanjing University of Chinese Medicine,Jiangsu Nanjing 210023,China;Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Cancer Prevention and Treatment,Jiangsu Nanjing 210023,China)

机构地区：[1]南京中医药大学附属医院,江苏南京210029 [2]南京中医药大学第一临床医学院,江苏南京210023 [3]江苏省中医药防治肿瘤协同创新中心,江苏南京210023

出　　处：《中医药临床杂志》2024年第5期811-816,共6页Clinical Journal of Traditional Chinese Medicine

基　　金：江苏省中医院高峰学术人才项目(y2021rc19);江苏省重点研发计划专项资金(社会发展)项目(BE2019771);江苏省研究生科研与实践创新计划项目(SJCX22-0762)。

摘　　要：连接蛋白过去被认为是由抑癌基因编码,但越来越多研究逐渐证实连接蛋白的促癌特性,特别是在癌症晚期。该文基于癌毒病机理论,梳理分析连接蛋白在肿瘤微环境中的促进作用与“癌毒”的致病特点和功能的相似相关性,认为连接蛋白促进肿瘤转移、加强肿瘤细胞治疗抗性是“癌毒流注”“癌毒缠绵”的关键病理机制,连接蛋白维持肿瘤酸性及瘀血微环境是“痰毒留恋”“瘀毒凝滞”的重要生物学基础,为进一步丰富发展癌毒病机理论科学内涵、阐释肿瘤微环境与癌毒病机的密切关系提供有益参考和依据。Connexins were previously thought to be encoded by tumor suppressor genes,but more and more studies have gradually confirmed its cancer-promoting properties,especially in advanced cancer.Based on the theory of cancer toxin pathogenesis,this paper analyzes the similar correlation between the promoting role of connexin in tumor microenvironment and the pathogenic characteristics and functions of cancer toxin,and holds that connexin promotes tumor metastasis and strengthens the resistance of tumor cells to treatment,which is the key pathological mechanism of cancer toxin flowing and lingering,and connexin maintains tumor acidity and blood stasis micro-environment,which is the important biological basis of“retention of phlegm poison”and“stagnation of blood stasis poison”,which is expected to provide useful reference and basis for further enriching the scientific connotation of the theory of cancer toxin pathogenesis and explaining the close relationship between tumor micro-environment and cancer toxin pathogenesis.

关 键 词：癌毒病机理论 连接蛋白 促癌作用 肿瘤微环境 

分 类 号：R273[医药卫生—中西医结合]