基于内质网应激反应探究针刺治疗卒中后抑郁的机制  

Based on Endoplasmic Reticulum Stress Response to Discusses the Mechanism of Acupuncture Treatment for Post-stroke Depression

作　　者：杨明岳 海英[2] YANG Mingyue;HAI Ying(Liaoning University of Traditional Chinese Medicine,Liaoning Shenyang 110847,China;The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Liaoning Shenyang 110847,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110847

出　　处：《中医药临床杂志》2024年第5期817-822,共6页Clinical Journal of Traditional Chinese Medicine

基　　金：辽宁省“兴辽英才计划”项目(XLYC2002104);广东省新黄埔中医药联合创新项目(2022IR002)。

摘　　要：卒中后抑郁(Post Stroke Depression,PSD)发生在脑卒中后,以情感低落、兴趣丧失、自我价值感下降、睡眠障碍等症状为主要临床表现。为探究针刺治疗PSD的具体分子机制,作者通过查阅近年来PubMed、CNKI、万方、维普等国内外数据库的资料和文献,将PSD与内质网应激反应(endoplasmic reticulum stress,ERS)的关系及针刺通过干预ERS来治疗PSD的临床研究和动物实验研究进行总结分析,厘清ERS的发生机制以及针刺干预ERS的可能靶点。该文章得出推论,针刺可能通过调节ERS相关通路蛋白,抑制炎症反应及超负荷ERS介导的细胞凋亡来改善PSD患者的临床症状。因此,该研究将针刺治疗手段调控PSD后发生ERS的相关靶点机制进行归纳,以期日后为针刺治疗PSD的可探索靶点方向提供新的思路及一定的科学依据。Post-stroke depression(PSD)occurs after stroke,with symptoms such as depression,loss of interest,decreased self-worth,and sleep disturbance as its main clinical manifestations.In order to explore the specific molecular mechanism of acupuncture treatment of PSD,the author reviewed the information and literature in domestic and foreign databases such as PubMed,CNKI,Wanfang,and VIP in recent years,and compared the relationship between PSD and endoplasmic reticulum stress(ERS).This paper summarizes and analyzes the clinical research and animal experimental studies on the relationship between acupuncture and ERS to treat PSD,and clarifies the mechanism of ERS and the possible targets of acupuncture to intervene in ERS.This article concluded that acupuncture may improve the clinical symptoms of PSD patients by regulating ERS-related pathway proteins,inhibiting inflammatory responses and overloading ERS-mediated apoptosis.Therefore,this study summarizes the relevant target mechanisms of ERS after acupuncture treatment regulates PSD,with a view to providing new ideas and certain scientific basis for the explorable target directions of acupuncture treatment of PSD in the future.

关 键 词：卒中后抑郁 内质网应激反应 针刺 眼针 未折叠蛋白反应 作用机制 异病同治 

分 类 号：R246.6[医药卫生—针灸推拿学] R743.3[医药卫生—中医临床基础]