基于“脾为之卫”探讨肠道菌群对自身免疫性甲状腺炎的作用机制  

Discussion on the Role of Intestinal Flora in Autoimmune Thyroiditis based on the Principle of“Spleen as the Guard”

作　　者：张鹏坤 金哲[2] 杨潇[2] ZHANG Pengkun;JIN Zhe;YANG Xiao(Liaoning University of Traditional Chinese Medicine Liaoning Shenyang 110000,China;The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine Liaoning Shenyang 110034,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110000 [2]辽宁中医药大学附属第二医院,辽宁沈阳110034

出　　处：《中医药临床杂志》2024年第5期838-843,共6页Clinical Journal of Traditional Chinese Medicine

基　　金：辽宁省中医药研究院(辽宁中医药大学附属第二医院)2022年度院级科研项目(编号:2022LZYY03);沈阳市中青年科技创新人才支持计划(编号:RC200370)。

摘　　要：“脾为之卫”指脾具有保护身体,抵御邪气的功能。“脾失之卫”则致气滞痰凝血瘀凝结于颈前而发为自身免疫性甲状腺炎(autoimmune thyroiditis,AIT),其发病机制与肠道菌群存在联系。“脾失之卫”则肠道菌群紊乱,脾运化和保护的功能受损。肠道菌群紊乱可能影响自身免疫性甲状腺炎的治疗和预后。肠道菌群可能是治疗AIT的主要作用靶点,以恢复肠道菌群为重点治疗AIT,为临床治疗提供新思路。“The spleen is the defender”means that the spleen has the function of protecting the body and resisting evil spirits.“Loss of spleen defense”will cause qi stagnation,phlegm and blood stasis to condense in the front of the neck,leading to autoimmune thyroiditis(AIT).Its pathogenesis is related to intestinal flora.If the spleen loses its defense,the intestinal flora will be disordered and the spleen’s transport,transformation and protection functions will be impaired.Disturbance of intestinal flora may affect the treatment and prognosis of autoimmune thyroiditis.Intestinal flora may be the main target for the treatment of AIT.Treating AIT focusing on restoring intestinal flora provides new ideas for clinical treatment.

关 键 词：脾为之卫 脾主运化 肠道菌群 自身免疫性甲状腺炎 肠道屏障 肠道菌群代谢 健脾中药 

分 类 号：R581.4[医药卫生—内分泌]