扶正消癥汤加减联合西医治疗正气亏虚型晚期肝癌的效果探讨  

Effect of Fuzheng Xiaozheng Decoction Combined with Western Medicine in the Treatment of Advanced Liver Cancer of Qi Deficiency Type

作　　者：胡俊伟 武喜眀 HU Junwei;WU Ximing(Henan Provincial Hospital for Infectious Diseases,The Sixth People’s Hospital of Zhengzhou,Henan Zhengzhou 450007,China)

机构地区：[1]河南省传染病医院,郑州市第六人民医院,河南郑州450007

出　　处：《中医药临床杂志》2024年第5期949-955,共7页Clinical Journal of Traditional Chinese Medicine

摘　　要：目的:探讨扶正消癥汤加减联合西医对正气亏虚型晚期肝癌患者的治疗效果。方法:选取该院2018年10月—2019年10月收治的112例正气亏虚型晚期肝癌患者,采用随机数字表分为西医组(56例,给予西医治疗)和联合组(56例,给予扶正消癥汤加减联合西医治疗),治疗周期为3个月。比较2组治疗前后中医症状评分,治疗效果,治疗前后血清肿瘤标志物水平和T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))水平,治疗期间不良反应和随访1年内生存率。结果:治疗前2组各项观察指标差异均无统计学意义(P>0.05);治疗后2组中医症状评分,血清甲胎蛋白、癌胚抗原、糖类抗原199、血管内皮生长因子水平均下降(P<0.05),联合组治疗后上述指标均低于西医组(P<0.05);治疗后联合组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均升高(P<0.05),西医组均降低(P<0.05),且治疗后联合组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均高于西医组(P<0.05);2组各项不良反应等级比较差异有统计学意义(P<0.05),且联合组发生率均低于西医组(P<0.05);联合组随访1年内生存率高于西医组(P<0.05)。结论:对正气亏虚型晚期肝癌采用扶正消癥汤加减联合西医治疗不仅可减轻症状,增强疗效,还可降低血清肿瘤标志物水平,增强机体T细胞免疫功能,且有助于减少不良反应,提高1年生存率。Objective:To explore the therapeutic effect of modified Fuzheng Xiaozheng Decoction combined with western medicine on patients with advanced liver cancer due to righteousness deficiency type.Methods:112 patients with advanced liver cancer with righteousness deficiency type admitted to our hospital from October 2018 to October 2019 were selected and divided into a Western medicine group(56 cases,given Western medicine treatment)and a combined group(56 cases,given Western medicine treatment)using a random number table.Modified Fuzheng Xiaozheng Decoction combined with Western medicine treatment,the treatment period is 3 months.Compare the TCM symptom scores,treatment effects,serum tumor marker levels and T lymphocyte subgroups(CD3+,CD4+,CD4+/CD8+)levels before and after treatment,adverse reactions during treatment and survival rate within 1 year of follow-up between the 2 groups.Results:There were no statistically significant differences in various observation indicators between the two groups before treatment(P>0.05);after treatment,the TCM symptom scores,serum alpha-fetoprotein,carcinoembryonic antigen,carbohydrate antigen 199,and vascular endothelial growth factor levels in the two groups were all the same.decreased(P<0.05),and the above indicators in the combined group were lower than those in the Western medicine group(P<0.05)after treatment;after treatment,CD3+,CD4+,and CD4+/CD8+ in the combined group all increased(P<0.05),while those in the Western medicine group all decreased(P<0.05),and the CD3+,CD4+,CD4+/CD8+ in the combination group after treatment were all higher than those in the Western medicine group(P<0.05);there was a statistically significant difference in the grades of adverse reactions between the 2 groups(P<0.05),and the combination group had higher The survival rates within 1 year of follow-up of the combined group were higher than those of the Western medicine group(P<0.05).Conclusion:For advanced liver cancer with deficiency of righteousness,using modified Fuzheng Xiaozheng Decoction combine

关 键 词：扶正消癥汤 正气亏虚 肝癌 肿瘤标志物 T淋巴细胞亚群 

分 类 号：R273[医药卫生—中西医结合]