2型糖尿病血糖控制中二甲双胍联合门冬胰岛素治疗的作用价值  

Role of Metformin Combined with Insulin Aspartate in Blood Glucose Control of Type 2 Diabetes Mellitus

作　　者：谢立凯[1] 孙亚东[1] XIE Likai;SUN Yadong(Department of Endocrine and Metabolic Diseases,Section I,Jilin Provincial People's Hospital,Changchun,Jilin Province,130012 China)

机构地区：[1]吉林省人民医院内分泌代谢病一科,吉林长春130012

出　　处：《糖尿病新世界》2024年第6期95-98,共4页Diabetes New World Magazine

摘　　要：目的探究二甲双胍与门冬胰岛素联合治疗2型糖尿病(Diabetes Mellitus Type 2,T2DM)对血糖的控制效果。方法选取2021年6月—2023年6月吉林省人民医院收治的100例T2DM患者为研究对象,以投掷硬币法分为参照组(n=50,二甲双胍治疗)、观察组(n=50,二甲双胍与门冬胰岛素联合治疗)。比较两组临床治疗效果、不良反应总发生率、血糖控制情况及血清炎性因子水平。结果观察组治疗总有效率(96.00%)高于参照组(84.00%),差异有统计学意义(χ^(2)=4.000,P<0.05)。两组不良反应总发生率对比,差异无统计学意义(P>0.05)。与治疗前相比,两组治疗半年后血糖水平、白细胞介素-6、白细胞介素-12水平均降低、白细胞介素-10水平升高,且观察组上述指标优于参照组,差异有统计学意义(P均<0.05)。结论二甲双胍与门冬胰岛素联合治疗T2DM患者时可提高疗效,患者血糖控制情况更佳,血清炎性因子水平也得到明显改善,安全性较高。Objective To explore the effect of combined treatment with metformin and insulin aspartate on blood glucose control in type 2 diabetes mellitus(T2DM).Methods A total of 100 T2DM patients admitted to Jilin Provincial People's Hospital from June 2021 to June 2023 were selected as the study subjects.They were divided into the reference group(n=50,treated with metformin)and the observation group(n=50,treated with a combination of metformin and insulin aspartate)by coin toss method.The clinical treatment efficacy,total incidence of adverse reactions,blood glucose control,and serum inflammatory factor levels between two groups were compared.Results The total effective rate of treatment in the observation group(96.00%)was higher than that in the reference group(84.00%),and the difference was statistically significant(χ^(2)=4.000,P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Compared with before treatment,blood glucose levels,interleukin-6,and interleukin-12 levels in two groups decreased,while interleukin-10 levels increased after six months of treatment,moreover,the observation group had better indexes than the reference group,and the differences were statistically significant(all P<0.05).Conclusion The combination of metformin and insulin aspartate can improve the efficacy of T2DM patients.Patients have better blood sugar control,significantly improved serum inflammatory factor levels,and higher safety.

关 键 词：2型糖尿病 二甲双胍 门冬胰岛素 血糖控制 临床疗效 不良反应 血清炎性因子 

分 类 号：R587.1[医药卫生—内分泌]