瑞格列奈片联合阿卡波糖片治疗老年2型糖尿病的效果及安全性  

Efficacy and Safety of Repaglinide Combined with Acarbose Tablets in the Treatment of Elderly Type 2 Diabetes

作　　者：和光宇 李良 HE Guangyu;Li Liang(Department of Pharmacy,Yanzhou District People's Hospital,Jining,Shandong Province,272100 China;Department of Gynecology,Yanzhou District People's Hospital,Jining,Shandong Province,272100 China)

机构地区：[1]济宁市兖州区人民医院药剂科,山东济宁272100 [2]济宁市兖州区人民医院妇科,山东济宁272100

出　　处：《糖尿病新世界》2024年第6期113-116,共4页Diabetes New World Magazine

摘　　要：目的分析老年2型糖尿病以阿卡波糖片治疗联合瑞格列奈片的效果。方法选取2022年1月—2023年12月济宁市兖州区人民医院收治的70例老年2型糖尿病患者为研究对象,根据双盲法分为对照组(35例,瑞格列奈片治疗)和观察组(35例,瑞格列奈片联合阿卡波糖片治疗),分析两组治疗有效率、血糖和胰岛素水平、脂代谢水平。结果观察组治疗有效率(94.29%)高于对照组(71.43%),差异有统计学意义(χ^(2)=6.437,P<0.05)。治疗后,观察组空腹血糖、餐后2 h血糖、空腹胰岛素水平低于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组三酰甘油、低密度脂蛋白胆固醇、总胆固醇低于对照组,差异有统计学意义(P均<0.05)。结论老年2型糖尿病以阿卡波糖片治疗联合瑞格列奈片效果甚佳。Objective To analyze the effect of acarbose tablets combined with repaglinide tablets in the treatment of elderly type 2 diabetes.Methods A total of 70 elderly patients with type 2 diabetes mellitus admitted to Yanzhou District People's Hospital of Jining City from January 2022 to December 2023 were selected as the research objects.According to the double-blind method,they were divided into control group(35 cases,repaglinide tablets for treatment)and observation group(35 cases,repaglinide tablets combined with acarbose tablets for treatment).The treatment efficiency,blood glucose and insulin levels,and lipid metabolism levels of the two groups were analyzed.Results The effective rate of treatment in the observation group(94.29%)was higher than that in the control group(71.43%),and the difference was statistically significant(χ^(2)=6.437,P<0.05).After treatment,the levels of fasting blood glucose,2 hours postprandial blood glucose and fasting insulin in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the levels of triglyceride,low density lipoprotein cholesterol and total cholesterol in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion In elderly patients with type 2 diabetes,the combination of acarbose tablets and repaglinide tablets is effective.

关 键 词：老年2型糖尿病 瑞格列奈片 阿卡波糖片 血脂 血糖 

分 类 号：R587.1[医药卫生—内分泌]