低通量与高通量血液透析对2型糖尿病肾病患者应激反应及微炎症状态的影响研究  

Effects of Low-flux and High-flux Hemodialysis on Stress Response and Microinflammatory Status in Patients with Type 2 Diabetic Nephropathy

作　　者：刘莉莉 刘利慧 LIU Lili;LIU Lihui(Department of Dialysis Room,Weifang Endocrine and Metabolic Disease Hospital,Weifang,Shandong Province,262600 China;Department of Nephrology Endocrinology,Zibo 148th Hospital,Zibo,Shandong Province,255300 China)

机构地区：[1]潍坊内分泌与代谢病医院透析室,山东潍坊262600 [2]淄博一四八医院肾病内分泌科,山东淄博255300

出　　处：《糖尿病新世界》2024年第6期174-176,180,共4页Diabetes New World Magazine

摘　　要：目的探讨低通量与高通量血液透析在2型糖尿病肾病(Diabetic Nephropathy,DN)患者中的应用价值。方法回顾性选取潍坊内分泌与代谢病医院于2021年5月—2023年6月收治的86例DN患者的临床资料,根据不同血液透析方式分为两组,各43例。对照组行低通量血液透析(Low-Flux Hemodialysis,LFHD),观察组行高通量血液透析(High Flux Hemodialysis,HFHD)。对比两组肾功能指标、应激反应、微炎症状态。结果治疗后,观察组血肌酐(380.21±20.18)μmol/L、血尿素氮(10.26±1.65)mmol/L、丙二醛(4.01±0.31)nmol/L、肿瘤坏死因子-α(72.09±5.25)ng/L、白介素-6(63.44±3.30)ng/L、超敏C反应蛋白(4.89±0.85)mg/L、降钙素原(1.53±0.20)μg/L低于对照组;肌酐清除率(37.89±3.55)m L/min、过氧化物歧化酶(89.01±2.44)U/m L、谷胱甘肽过氧化物酶(166.20±13.38)U/L高于对照组,差异有统计学意义(P均<0.05)。结论HFHD能有效改善DN患者肾功能、应激水平,减轻微炎症状态。Objective To investigate the application value of low-flux and high-flux hemodialysis in patients with type 2 diabetic nephropathy(DN).Methods Clinical data of eighty-six patients with DN admitted to Weifang Endocrine and Metabolic Disease Hospital from May 2021 to June 2023 were retrospectively selected,and divided into 2 groups with forty-three cases each according to different hemodialysis methods.The control group had low-flux hemodialysis(LFHD),and the observation group had high-flux hemodialysis(HFHD).Renal function indexes,stress response and microinflammation were compared between the two groups.Results After treatment,the serum creatinine was(380.21±20.18)μmol/L,blood urea nitrogen was(10.26±1.65)mmol/L,malondialdehyde was(4.01±0.31)nmol/L,tumor necrosis factor-αwas(72.09±5.25)ng/L and interleukin-6 was(63.44±3.30)ng/L,hypersensitive C-reactive protein was(4.89±0.85)mg/L,and procalcitonin was(1.53±0.20)μg/L in the observation group,lower than those of control group;creatinine clearance was(37.89±3.55)mL/min,peroxidase dismutase was(89.01±2.44)U/mL,glutathione peroxidase was(166.20±13.38)U/L in the observation group,higher than those of control group,and the differences were statistically significant(all P<0.05).Conclusion HFHD can effectively improve renal function,stress level and reduce micro-inflammation in patients with DN.

关 键 词：2型糖尿病肾病 低通量血液透析 高通量血液透析 肾功能指标 应激反应 微炎症状态 

分 类 号：R587.1[医药卫生—内分泌]