阿柏西普联合羟苯磺酸钙在糖尿病视网膜病变黄斑水肿中的疗效观察  

Clinical Observation of Aflibercept Combined with Calcium Dobesilate in Macular Edema of Diabetes Retinopathy

作　　者：马婵娟[1] 陈晓刚[1] 董冠斌 MA Chanjuan;CHEN Xiaogang;DONG Guanbin(Department of Ophthalmology,Tianshui Traditional Chinese Medicine Hospital,Tianshui,Gansu Province,741000 China)

机构地区：[1]甘肃省天水市中医医院眼科,甘肃天水741000

出　　处：《糖尿病新世界》2024年第6期191-193,198,共4页Diabetes New World Magazine

摘　　要：目的探讨阿柏西普联合羟苯磺酸钙在糖尿病视网膜病变黄斑水肿中的治疗效果。方法回顾性选取2020年10月—2023年10月天水市中医医院收治的100例糖尿病视网膜病变黄斑水肿患者的临床资料,以不同的治疗方案分为两组,各50例,对照组患者给予阿柏西普玻璃体腔内注射,研究组患者则在对照组基础上联合口服羟苯磺酸钙胶囊。比较两组的治疗效果。结果研究组患者治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗后,两组的眼压均明显降低,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组的最佳矫正视力均明显升高,且研究组高于对照组,差异有统计学意义(P<0.05);治疗后,两组的黄斑中心凹厚度均明显减小,且研究组小于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论在阿柏西普玻璃体腔内注射治疗糖尿病视网膜病变黄斑水肿过程中联用羟苯磺酸钙,疗效安全显著,对促进患者病情恢复、提高生活质量具有积极意义。Objective To investigate the therapeutic effect of albacicept combined with calcium dobesilate in macular edema of diabetes retinopathy.Methods The clinical data of 100 patients with macular edema of diabetic retinopathy in Tianshui Traditional Chinese Medicine Hospital in from October 2020 to October 2023 were retrospectively selected and divided into two groups according to different treatment schemes,with 50 cases in each group.The control group was given intravitreal injection of aflibercept,while the study group was combined with oral calcium dobesilate capsules on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the intraocular pressure of the two groups decreased significantly,and that of the study group was lower than the control group,and the difference was statistically significant(P<0.05).After treatment,the best corrected visual acuity of the two groups increased significantly,and that of the study group was higher than the control group,and the difference was statistically significant(P<0.05).After treatment,the macular foveal thickness of the two groups decreased significantly,and that of the study group was lower than the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of oral calcium dobesilate during intravitreal injection of aflibercept in the treatment of macular edema in diabetes retinopathy is safe and has positive significance in promoting the recovery of patients'condition and improving their quality of life.

关 键 词：阿柏西普 羟苯磺酸钙 黄斑水肿 眼压 黄斑中心凹厚度 

分 类 号：R587.1[医药卫生—内分泌]