基于营养评估的综合营养支持对肝癌化疗栓塞术后患者免疫功能、营养状态及生命质量的影响  

Effect of comprehensive nutritional support based on nutritional assessment on immune function,nutritional status and quality of life in patients with HCC after transcatheter arterial chemoembolization

作　　者：王粉芝 权维维 魏莹 赵宗辽[2] Wang Fenzhi;Quan Weiwei;Wei Ying;Zhao Zongliao(Tangdu Hospital,Air Force Medical University,Xi'an 710032,China;The Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang Shaanxi 712099,China)

机构地区：[1]空军军医大学唐都医院,西安710032 [2]陕西中医药大学第二附属医院,陕西咸阳712099

出　　处：《保健医学研究与实践》2023年第S02期150-153,共4页Health Medicine Research and Practice

基　　金：国家自然科学基金资助项目(81703924)。

摘　　要：目的探讨肝细胞癌(HCC)患者行化疗栓塞术(TACE)后应用营养评估工具联合综合营养支持对患者免疫功能、营养状态及生命质量的影响。方法选取2019年9月—2022年9月于空军军医大学唐都医院就诊的113例HCC患者作为研究对象,根据患者是否通过营养评估及综合营养支持方式治疗,将患者分为综合营养支持组即观察组(52例)与未进行综合营养支持组即对照组(61例)。比较2组患者组间、组内免疫功能、营养状态及生命质量等水平的差异性。结果干预前,2组患者免疫功能、营养状态及生命质量等指标水平比较,差异无统计学意义(P>0.05)。干预后,观察组患者前白蛋白(PAB)、血清白蛋白(ALB)、血清总蛋白(TP)、身体质量指数(BMI)、CD3^(+)水平、CD4^(+)水平、CD8^(+)水平、QOL-LC评分均高于对照组,而谷草转氨酶(AST)、谷丙转氨酶(ALT)、间接胆红素(IBIL)水平均低于对照组,差异均有统计学意义(P<0.05)。结论基于营养评估结果实施综合营养支持干预,可以有效促进HCC患者TACE术后免疫功能、营养状态、生命质量的恢复,并在一定程度上恢复肝损伤。Objective To evaluate the effect of a nutritional assessment tool combined with comprehensive nutritional support on immune function,nutritional status and quality of life in patients with HCC after transcatheter arterial chemoembolization.Methods A total of 113 HCC patients treated in Tangdu Hospital,Air Force Medical University from September 2019 to September 2022 were selected as study participants,who were allocated to an observation group(n=52)with comprehensive nutrition support and a control group(n=61)without comprehensive nutrition support according to whether the patients have received nutritional assessment and comprehensive nutritional support.The differences in immune function,nutritional status,and quality of life between the two groups were observed.Results No significant difference was found in the levels of immune function,nutritional status,and quality of life between the two groups before intervention(P>0.05).Prealbumin(PAB),serum albumin(ALB),serum total protein(TP),body mass index(BMI),CD3^(+)level,CD4^(+)level,CD8^(+)level,and quality of life-liver cancer(QOL-LC)score in the observation group were significantly higher than those in the control group,while aspartate aminotransferase(AST),alanine aminotransferase(ALT)and indirect bilirubin(IBIL)levels were significantly lower than those in the control group(P<0.05).Conclusion Comprehensive nutritional support intervention based on nutritional assessment results can effectively promote the recovery of immune function,nutritional status,and quality of life of HCC patients after TACE,and restore liver injury to a certain extent.

关 键 词：营养评估 营养支持 肝细胞癌 化疗 肝动脉化疗栓塞术 免疫功能 营养状态 生命质量 

分 类 号：R473.73[医药卫生—护理学]