瑞草油防治蚊虫叮咬及止痒效果评价研究  

Evaluation Research of the Efficacy of Ruicao Oil against Mosquito Bites and Itching

作　　者：张郁林 毛鑫 万安凤 黄志云 孙维广 Zhang Yulin;Mao Xin;Wan Anfeng;Huang Zhiyun;Sun Weiguang(Guangzhou Baiyunshan Xingqun Pharmaceutical Co.,Ltd.,Guangzhou 510288,China)

机构地区：[1]广州白云山星群(药业)股份有限公司,广东广州510288

出　　处：《广东化工》2024年第8期135-137,共3页Guangdong Chemical Industry

摘　　要：目的:通过客观定量的评价方法,研究瑞草油对蚊虫的室内、室外驱杀及止痒效果。方法:通过统计有效保护时间、半数击倒时间KT_(50)、存活率等,验证瑞草油在室内外对白纹伊蚊的驱杀效果;以磷酸组胺致痒的豚鼠为动物模型,评价瑞草油的止痒功效。结果:以1.5μL/cm^(2)瑞草油均匀涂抹手背皮肤,在室内对白纹伊蚊的有效保护时间为6 h,根据相关标准,效果评级为A级;在室外对白纹伊蚊的有效保护时间为4 h,药效合格;在室内对白纹伊蚊的半数击倒时间KT_(50)为1.65 min,2.87 min死亡率达100%,效果评级为A级;在室内杀蚊幼试验中,48 h杀蚊幼的有效浓度≥0.005%,杀灭率为93.33%,药效结果为有效;瑞草油有效降低皮肤组织中的组胺浓度,瘙痒时间抑制率为53.76%,优于复方醋酸地塞米松乳膏(38.35%)。结论:瑞草油在防治蚊虫叮咬及止痒方面表现出显著效果,可丰富防控登革热等蚊媒传播疾病的手段,以及为其他药油产品开展防治蚊虫叮咬药效评价提供参考。Objective:To study the indoor and outdoor repellent and antipruritic effects of Ruicao oil on mosquitoes through an objective and quantitative evaluation method.Methods:The effective protection time,the half-knockdown time(KT_(50))and survival rate were calculated to verify the indoor and outdoor repellent effects of Ruicao oil on Aedes albopictus adults,as well as the indoor killing effect of adults and larvae.Guinea pigs with histamine phosphate-induced itching were used as an animal model to evaluate the antipruritic efficacy of Ruicao oil.Results:By applying 1.5μL/cm^(2)of the oil to the skin of the back of the hand,The effective protection time against Aedes albopictus indoors was 6 h,which was rated as A grade according to relevant standards.The effective protection time against Aedes albopictus outdoors was 4 h,which efficacy was qualified.The KT_(50)of Aedes albopictus indoors was 1.65 min,and the mortality rate reached 100%in 2.87 min,which effect was rated as A grade.In the indoor mosquito larvae killing test,the effective concentration of 48 h was≥0.005%,and the killing rate was 93.33%,which result was effective.Ruicao oil effectively reduced histamine concentration in skin tissues with an itch time inhibition rate of 53.76%,which was superior to compounded dexamethasone acetate cream(38.35%).Conclusion:Ruicao oil has shown significant efficacy against mosquito bites and itching,which can enrich the means of preventing mosquito-borne diseases,such as dengue fever,as well as provide a reference for the evaluation of the efficacy of other medicinal oil products against mosquito bites and itching.oil products against mosquito bites and itching.

关 键 词：瑞草油 蚊虫叮咬 止痒 评价研究 

分 类 号：R285.5[医药卫生—中药学]