内镜下贲门松弛紧缩术联合药物治疗难治性反流性食管炎的临床效果  

Clinical Effect of Endoscopic Cardial Relaxation and Compression Combined with Drugs in the Treatment of Refrac- tory Reflux Esophagitis

作　　者：陈芳 秦荣 陈炜璋 柴芳时 阮开学 Chen Fang;Qin Rong;Chen Weizhang;Chai Fangshi;Ruan Kaixue(Department of Health Management,Dongguan Binhaiwan Central Hospital,Dongguan 523900,Guangdong Province,China;Department of Gastroenterology,Dongguan Binhaiwan Central Hospital,Dongguan 523900,Guangdong Province,China)

机构地区：[1]东莞市滨海湾中心医院健康管理科,广东东莞523900 [2]东莞市滨海湾中心医院消化内科,广东东莞523900

出　　处：《中外医药研究》2024年第10期30-32,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

基　　金：东莞市社会发展科技项目(编号:20211800900402)。

摘　　要：目的:分析内镜下贲门松弛紧缩术联合药物治疗难治性反流性食管炎(RGERE)的临床效果.方法:选取2021年10月—2023年3月东莞市滨海湾中心医院收治的RGERE患者60例作为研究对象,随机分为对照组(药物治疗)与试验组(内镜下贲门松弛紧缩术联合药物治疗),各30例.比较两组干预效果.结果:治疗后,两组食管内pH值、压力高于治疗前,胃食管反流病-健康相关生活质量评分低于治疗前,试验组优于对照组,差异有统计学意义(P<0.05);治疗后,两组病理学积分低于治疗前,试验组低于对照组,差异有统计学意义(P<0.05);试验组总有效率高于对照组,不良反应发生率低于对照组,差异有统计学意义(P<0.05).结论:针对RGERE患者,采取内镜下贲门松弛紧缩术治疗,可缓解临床症状,提高治疗有效率,且安全性较高,可推广.Objective:To analyze the clinical effect of endoscopic cardial relaxation and compression combined with drugs in the treatment of refractory reflux esophagitis(RGERE).Methods:Sixty patients with RGERE admitted to Dongguan Binhaiwan Central Hospital from October 2021 to March 2023 were selected as the study objects,and were randomly divided into control group(drug treatment)and experimental group(endoscopic cardiac relaxation and contraction combined drug treatment),with thirty cases in each group.The intervention effect of the two groups was compared.Results:After treatment,esophageal pH value and pressure were higher than before treatment,and GERD health-related quality of life score was lower than before treatment,the experimental group was better than the control group,the difference was statistically significant(P<0.05);after treatment,the pathological scores of the two groups were lower than before treatment,and the experimental group was lower than the control group,the difference was statistically significant(P<0.05);the total effective rate of experimental group was higher than that of control group,and the incidence of adverse reactions was lower than that of control group,the difference was statistically significant(P<0.05).Conclusion:For patients with RGERE,endoscopic cardial relaxation and constriction therapy can relieve clinical symptoms,improve treatment efficiency,and have high safety,which can be popularized.

关 键 词：难治性反流性食管炎 贲门松弛紧缩术 内镜 黏膜套扎 

分 类 号：R655.4[医药卫生—外科学]