血清IgG、白细胞介素-6、维生素D检测在肺炎支原体感染合并支气管哮喘患儿中的应用研究  

Application of Serum IgG, Interleukin-6 and Vitamin D Detection in Children with Mycoplasma Pneumoniae Infec- tion and Bronchial Asthma

作　　者：吴汪丽[1] 彭云[1] 黄焕平 袁宝莉[1] Wu Wangli;Peng Yun;Huang Huanping;Yuan Baoli(Department of Pediatrics,the Second Affiliated Hospital of Guangzhou Medical University,Guangzhou 510260,Guangdong Prov-ince,China)

机构地区：[1]广州医科大学附属第二医院儿科,广东广州510260

出　　处：《中外医药研究》2024年第10期148-150,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:分析血清免疫球蛋白G(IgG)、白细胞介素-6(IL-6)、维生素D检测在肺炎支原体(MP)感染合并支气管哮喘患儿中的应用价值.方法:选取2018年1月—2022年8月广州医科大学附属第二医院儿科住院部收治的MP感染患儿103例为研究对象,根据是否合并支气管哮喘,分为未合并哮喘组(n=68)及合并哮喘组(n=35).分别采用酶联免疫法、电化学发光法、液相色谱串联质谱检测患儿血清IgG、IL-6、维生素D水平.结果:合并哮喘组血清IgG、IL-6水平高于未合并哮喘组,维生素D水平低于未合并哮喘组,差异有统计学意义(P<0.001);Pearson相关系数分析结果显示,MP感染合并支气管哮喘发生率与血清IgG、IL-6水平呈正相关(r=0.925,P=0.029;r=0.931,P=0.048),与血清维生素D水平呈负相关(r=-0.964,P=0.021).结论:血清IgG、IL-6、维生素D水平可有效反映MP感染合并支气管哮喘患儿的病情,为其后续治疗提供参考依据.Objective:To analyze the value of serum immunoglobulin G(IgG),interleukin-6(IL-6)and vitamin D detection in children with mycoplasma pneumoniae(MP)infection complicated with bronchial asthma.Methods:A total of one hundred and three children with MP infection admitted to the inpatient department of pediatrics of the Second Affiliated Hospital of Guangzhou Medical University from January 2018 to August 2022 were selected as the study objects.According to whether they had bronchial asthma,they were divided into two groups:the group without asthma(n=68)and the group with asthma(n=35).Serum IgG,IL-6 and vitamin D levels were detected by enzyme-linked immunoassay,electrochemiluminescence and liquid chromatography-tandem mass spectrometry.Results:Serum IgG and IL-6 levels in the group with asthma were higher than those in the group without asthma,and vitamin D levels were lower than those in the group without asthma,the difference was statistically significant(P<0.001);Pearson correlation coefficient analysis showed that the incidence of MP infection combined with bronchial asthma was positively correlated with serum IgG and IL-6 levels(r=0.925,P=0.029;r=0.931,P=0.048),negatively correlated with serum vitamin D levels(r=-0.964,P=0.021).Conclusion:Serum IgG,IL-6 and vitamin D levels can effectively reflect the condition of children with MP infection complicated with bronchial asthma,and provide reference for subsequent treatment.

关 键 词：血清免疫球蛋白G 白细胞介素-6 维生素D 肺炎支原体 支气管哮喘 

分 类 号：R725.6[医药卫生—儿科]