活血养心方治疗射血分数减低型心力衰竭疗效分析  

Efficacy analysis of Huoxue Yangxin Decoction in the treatment of heart failure with reduced ejection fraction

作　　者：王怡彤 王丽 范燕宾 Wang Yitong;Wang Li;Fan Yanbin(Zhengzhou Ninth People's Hospital Geriatrics Center,Zhengzhou 450000,China)

机构地区：[1]郑州市第九人民医院老年医学中心,河南郑州450000

出　　处：《华北理工大学学报（医学版）》2024年第3期200-205,共6页Journal of North China University of Science and Technology：Health Sciences Edition

基　　金：河南省医学科技攻关计划项目(编号:LHGJ20220831)。

摘　　要：目的探讨活血养心方治疗射血分数减低型心力衰竭(HFrEF)的疗效。方法选取2021年1月~2023年1月在郑州市第九人民医院治疗的HFrEF患者84例为研究对象,以随机数表法分为观察组和对照组,各42例。对照组口服沙库巴曲缬沙坦钠片+达格列净+富马酸比索洛尔片+螺内酯,观察组在对照组治疗基础上给予自拟活血养心方治疗。使用χ^(2)检验比较两组患者的临床疗效、不良反应情况,采用成组t检验比较两组左心室功能指标、血清心肌标志物水平、6min步行试验水平。结果(1)治疗后观察组总有效率为95.24%,对照组80.95%(P<0.05)。(2)治疗后观察组LVEF(53.21±7.51)%,LVESD(40.26±4.35)mm、LVEDD(56.25±4.71)mm,对照组分别为(45.13±2.17)%、(46.43±3.17)mm、(60.23±4.36)mm,两组比较差异有统计学意义(P<0.05)。(3)治疗后观察组NT-pro-BNP(1954.52±319.82)pg/mL、Gal-3(9.28±1.42)ng/mL、IL-6(11.13±1.27)ng/L、IL-33(40.51±2.14)ng/L,对照组分别为(2473.41±532.14)pg/mL、(10.49±1.81)ng/mL、(19.10±1.35)ng/L、(48.84±2.72)ng/L,观察组各指标明显低于对照组(P<0.05)。(4)治疗后观察组患者6min步行试验(194.62±44.71)m,对照组(152.16±35.18)m,观察组优于对照组(P<0.05)。(5)观察组不良反应总发生率为4.76%,对照组19.75%(P<0.05)。结论活血养心方可以有效提高HFrEF患者疗效、改善心功能、降低炎症反应,减少不良反应发生,与“新四联”联合用药,是一种可行的中西医结合治疗方案。Objective To investigate the efficacy of Huoxue Yangxin Decoction in the treatment of heart failure with reduced ejection fraction(HFrEF).Methods A total of 84 patients with HFrEF treated at the Ninth People's Hospital of Zhengzhou from January 2021 to January 2023 were selected as the study subjects.They were randomly divided into an observation group and a control group,with 42 patients in each group.The control group received oral sacubitril valsartan sodium tablets,dapagliflozin,bisoprolol fumarate tablets,and spironolactone.The observation group was treated with self-designed Huoxue Yangxin Decoction in addition to the treatment given to the control group.Chi-square test was used to compare the clinical efficacy and adverse reactions between the two groups.Paired t-test was used to compare the left ventricular function indicators,serum myocardial marker levels,and 6-minute walk test levels between the two groups.Results(1)The total effective rate was 95.24%in the observation group and 80.95%in the control group after treatment(P<0.05).(2)After treatment,the LVEF was(53.21±7.51)%and LVESD was(40.26±4.35)mm,LVEDD was(56.25±4.71)mm in the observation group,while in the control group,they were(45.13±2.17)%,(46.43±3.17)mm,and(60.23±4.36)mm,respectively.The difference between the two groups was statistically significant(P<0.05).(3)After treatment,NT-pro-BNP was(1954.52±319.82)pg/mL,Gal-3 was(9.28±1.42)ng/mL,IL-6 was(11.13±1.27)ng/L,and IL-33 was(40.51±2.14)ng/L in the observation group,while in the control group,they were(2473.41±532.14)pg/mL,(10.49±1.81)ng/mL,(19.10±1.35)ng/L,and(48.84±2.72)ng/L,respectively.The indicators in the observation group were significantly lower than those in the control group(P<0.05).(4)After treatment,the 6-minute walk test was(194.62±44.71)m in the observation group and(152.16±35.18)m in the control group,showing that the observation group was better than the control group(P<0.05).(5)The total incidence of adverse reactions was 4.76%in the observation group and 19.75%

关 键 词：活血养心方 心力衰竭 左心室射血分数 心功能 

分 类 号：R541.6[医药卫生—心血管疾病]