奶桑中的木脂素类成分研究  

Study on Lignans from Morus macroura Miq.

作　　者：庞文慧 丁玲 周学梅 武学文 张兴杰 张芮菡 李晓莉 肖伟烈 PANG Wenhui;DING Ling;ZHOU Xuemei;WU Xuewen;ZHANG Xingjie;ZHANG Ruihan;LI Xiaoli;XIAO Weilie(School of Pharmacy,Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education,Yunnan Characteristic Plant Extraction Laboratory,Yunnan Provincial Center for Research&Development of Natural Products,Yunnan University,Kunming 650500,Yunnan,China)

机构地区：[1]云南大学药学院,教育部自然资源药物化学重点实验室,云南特色植物提取实验室,云南省天然产物转化与应用重点实验室,云南昆明650500

出　　处：《云南大学学报（自然科学版）》2024年第3期549-554,共6页Journal of Yunnan University(Natural Sciences Edition)

基　　金：国家自然科学基金(22167021);云岭学者项目(82260682)。

摘　　要：综合应用正相硅胶柱层析、凝胶柱色谱、大孔树脂柱层析等多种分离手段对奶桑(Morus macroura Miq)乙酸乙酯相进行分离纯化,并利用1D、2D NMR技术进行结构鉴定.共分离纯化得到9个木脂素类化合物,分别为moracin O(1),moracin P(2),moracin M(3),moracin R(4),(-)-(7R,8S)-dehydrodiconiferyl alcohol(5),(+)-lariciresinol(6),balanophonin(7),(7S,8R)-5-methoxyl-balanophonin(8)和hedyotisol A(9),其中化合物1,4~9为首次从该植物中分离得到.此外对部分化合物(1~5,7,9)进行抗炎活性测试,结果表明化合物9具有较弱的抗炎活性.Sephadex LH-20,silica gel column chromatography,macroporous resin column chromatography and other separation methods were comprehensively used to separate and purify the ethyl acetate phase of Morus macroura Miq.,and 1D and 2D NMR were used to identify the structure.Nine lignan compounds were isolated and purified,namely moricin O(1),moricin P(2),moricin M(3),moricin R(4),(−)-(7R,8S)-dihydroniconiferol alcohol(5),(+)-laricilinol(6),balanophonin(7),(7S,8R)-5-methoxyl balanophonin(8)and hedyotisol A(9),among which compounds 1,4−9 were firstly isolated from this plant.In addition,some compounds(1−5,7,9)were tested for anti-inflammatory activity,and compound 9 showed weak anti-inflammatory activity.

关 键 词：奶桑 化学成分 木脂素 抗炎活性 

分 类 号：Q949.737.4[生物学—植物学]