线粒体调控细胞命运途径的研究进展  

Research progress on mitochondria regulation of cell fate pathways

作　　者：安宇轩 AN Yuxuan(Hengyang Medical School,University of South China,Hengyang 421001,Hunan,China)

机构地区：[1]南华大学衡阳医学院,湖南衡阳421001

出　　处：《中南医学科学杂志》2024年第3期496-500,共5页Medical Science Journal of Central South China

基　　金：南华大学大学生创新项目(202110555091)。

摘　　要：线粒体是动态且高度可塑的细胞器,是细胞的能量工厂,具有调控细胞内能量生成、代谢以及信号转导的作用。研究表明,线粒体调控细胞增殖、凋亡、衰老、分化、细胞周期等与细胞命运密切相关的生物学过程,表明线粒体在调控细胞命运过程中发挥着重要的生物学作用。本文综述了线粒体能量代谢、线粒体蛋白、活性氧、线粒体DNA、线粒体动力学调控细胞命运的机制,以期为细胞命运的调控提供新的策略和靶点。Mitochondria are dynamic and highly plastic organelles,and are the energy factories of cells,playing a role in regulating intracellular energy generation,metabolism,and signal transduction.Researches have shown that mitochondria regulate many biological processes,such as proliferation,apoptosis,aging,differentiation,and cell cycle,indicating that mitochondria play an important biological role in regulating cell fate.This article reviews the mechanisms by which mitochondrial energy metabolism,mitochondrial proteins,reactive oxygen species,mitochondrial DNA,and mitochondrial dynamics regulate cell fate,in order to provide new strategies and targets for the regulation of cell fate.

关 键 词：线粒体 调控 细胞命运 

分 类 号：Q244[生物学—细胞生物学]