Potential efficacy and mechanism of medicinal plants on chronic kidney disease-associated vascular calcification:a review  

作　　者：Han-Qing Zhang Shuang Wu Xin Chen Ya-Xuan Fang Qiu-Mei Lan Zi-Jun Zhou Yan-Heng Qiao Jie Li Yan-Ru Zhao Ming Pei Bo Yang 

机构地区：[1]Department of Nephropathy,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China [2]National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China

出　　处：《Traditional Medicine Research》2024年第9期21-31,共11页TMR传统医学研究

摘　　要：Vascular calcification is a crucial risk factor that affects the incidence and mortality of cardiovascular disease in chronic kidney disease patients.Modern medicine relies on calcium-phosphorus binding agents,calcium mimetics,active vitamin D,and hemodialysis to prevent and treat vascular calcification,however,their efficacy is unsatisfactory and adverse reactions often occur.Medical plant therapy can act as an integrative regulator in patients with chronic kidney disease-associated vascular calcification,which can significantly improve patients’symptoms,but its specific mechanism has not been fully elucidated yet.In this paper,we reviewed the domestic and international theoretical studies on the pathogenesis mechanism of chronic kidney disease-associated vascular calcification in recent years,summarized eight active ingredients of medicinal plants as well as four compound formulas for improving chronic kidney disease-associated vascular calcification,and explored the mechanism of action of herbal medicine,which will provide a new strategy for promoting the prevention and treatment of vascular calcification.

关 键 词：chronic kidney disease chronic kidney disease-mineral and bone disorder(CKD-MBD) vascular calcification medicinal plants herbal monomers 

分 类 号：R692[医药卫生—泌尿科学]