The role of FMO3 in metabolic diseases  

作　　者：Hui-Wen Ren He-Yuan Lu Hai-Bo Zhang Rui-Jing Zhang Che Bian 

机构地区：[1]Advanced Institute for Medical Sciences,Dalian Medical University,Dalian 116044,China [2]College of Basic Medical Sciences,Dalian Medical University,Dalian 116044,China [3]Department of Nephrology,Xijing Hospital,The Fourth Military Medical University,Xi’an 710032,China [4]Department of Endocrinology and Metabolism,The Fourth Affiliated Hospital of China Medical University,Shenyang 110032,China

出　　处：《Traditional Medicine Research》2024年第9期42-50,共9页TMR传统医学研究

基　　金：supported by the Youth Project Supported by Basic Scientific Research Fund of Human Provincial Education Department(Grant No.JYTQN202351);the Innovation Support Plan for Young and Middle-aged People of Shenyang City(Grant No.RC210460);the Medical and Industrial Cross-Project of Natural Science Foundation of Liaoning Province(Grant No.2022-YGJC-24);the Doctoral Research Initiation Fund Project of Liaoning Province(Grant No.2021-BS-206).

摘　　要：Flavin containing monooxygenase 3(FMO3)is a member of the flavin monooxygenase family,which can oxidize the precursor Trimethylamine(TMA)provided from food to produce Trimethylamine N-oxide(TMAO).The autosomal recessive inherited disease caused by partial functional loss of Fmo3 gene,which leads to excessive excretion of TMA in body fluids and emits fishy odor,is called Fish Odor Syndrome or Trimethylaminuria.This disease has been documented for 3,000 years ago and was first reported in the case report in 1970.FMO3 mainly exists in the liver and can participate in the TMA-TMAO metabolic balance in intestinal microorganisms,liver,and kidneys,closely related to insulin resistance,diabetes,cholesterol metabolism,and cardiovascular disease.Due to its wide range of catalytic substrates and low susceptibility to metabolite accumulation,its role in drug metabolism,new drug development,and discovery of new drug targets are increasingly valued.This review will summarize the research progress on the metabolic process and localization of FMO3,congenital genetic defects,metabolic diseases,and its related possible mechanisms.

关 键 词：metabolic diseases FMO3 TMA TMAO 

分 类 号：R589[医药卫生—内分泌]