替米沙坦的合成工艺路线综述  

A Review of Synthetic Routes for Telmisartan

作　　者：王宁 张晗 吴馨仪 金玉祥 陈凯林 金诺琪 曹文博 杜剡渊 孙铭锐 代凤丽 夏春年[1] WANG Ning;ZHANG Han;WU Xinyi;JIN Yuxiang;CHEN Kailin;JIN Nuoqi;CAO Wenbo;DU Shanyuan;SUN Mingrui;DAI Fengli;XIA Chunnian*(School of Pharmaceutical Sciences,Zhejiang University of Technology,Hangzhou,Zhejiang 310014,China;Microfluidic Tech Co.,Ltd.,Hangzhou,Zhejiang 310056,China;Zhejiang Juxian Pharmaceutical Technology Co.,Ltd.,Taizhou,Zhejiang 317016,China)

机构地区：[1]浙江工业大学药学院,浙江杭州310014 [2]杭州微流汇科技有限公司,浙江杭州310056 [3]浙江聚贤医药科技有限公司,浙江台州317016

出　　处：《浙江化工》2024年第5期20-27,共8页Zhejiang Chemical Industry

基　　金：浙江工业大学横向项目;浙江聚贤医药科技有限公司(KYY-HX-20190007)。

摘　　要：替米沙坦,一种抗高血压药,凭借其控制血压平稳和作用长效等优点,在高血压管理方面占据重要地位。本文依照原研路线的合成顺序,将替米沙坦分子分为3个区块,以区块的合成为目标,对每个区块的合成方式进行分类综述,并附上思维导图,旨在明晰现有路线的原料、合成途径与最终产物,便于后续合成路线的设计与选取。Telmisartan,an antihypertensive drug,occupies an important position in the management of hypertension due to its advantages of stable blood pressure control and long-term effect.In this paper,according to the synthesis order of the original route,the telmisartan molecule is divided into three blocks,and the synthesis method of each block is classified and summarized with the synthesis of blocks as the goal,and a mind map is attached,aiming to clarify the raw materials,synthesis pathways and final products of the existing routes,so as to facilitate the design and selection of subsequent synthesis routes.

关 键 词：替米沙坦 综述 合成 思维导图 

分 类 号：TQ463[化学工程—制药化工]