基于数据挖掘探讨《医方类聚·咳嗽门》用药规律  

Discussion on the Medication Law in the Yi Fang Lei Ju·Ke Sou Men Based on Data Mining

作　　者：陈硕[1] 秦万里 罗刚[1] CHEN Shuo;QIN Wanli;LUO Gang(Beijing Gulou Traditional Chinese Medicine Hospital,Beijing 100009,China;Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京市鼓楼中医医院,北京100009 [2]北京中医药大学,北京100029

出　　处：《中国中医药图书情报杂志》2024年第4期114-119,共6页Chinese Journal of Library and Information Science for Traditional Chinese Medicine

基　　金：北京中医药大学高层次人才科研启动经费(90011451310006);国家重点研发计划(2019YFC1710105)。

摘　　要：目的 探讨《医方类聚·咳嗽门》中治疗咳嗽病用药规律,为临床提供参考和借鉴。方法 纳入《医方类聚·咳嗽门》所载咳嗽病治疗处方,对方中使用药物的用药频次、性味归经、功效等进行频数统计,对高频药物进行药物类别、关联规则及聚类分析。结果 共纳入方剂1 332首,包括中药378味,药味多在12味以下,高频药物包括甘草、半夏、人参、杏仁、陈皮、茯苓、生姜、五味子等,药性以温性为主,药味以辛、苦、甘味为主,主要归肺经、脾经,功效类别以化痰止咳平喘药及补虚药为主;关联规则共得出2联组合18项,3联组合34项,4联组合3项,多为健脾祛湿、宣肺化痰药物组合,同时得出核心药物组为二陈汤加减,聚类分析得出6个药物组群,具有清肺润肺、理气健脾、燥湿化痰及温阳功效特点。结论 明代以前医家对咳嗽病的处方用药相对精简,以温化为主,润燥合宜,肺脾同治,重视理气化痰。Objective To analyze the medication law in the treatment of cough in Yi Fang Lei Ju·Ke Sou Men;To provide the basis and reference for the clinical treatment of cough.Methods Prescriptions for the treatment of cough recorded in Yi Fang Lei Ju·Ke Sou Men were included.Frequency statistics was performed on the frequency of medication,property,taste,meridian,and efficacy of drugs.Drug subcategories,association rules,and clustering analysis were performed on high-frequency drugs.Results A total of 1 332 prescriptions were collected,including 378 kinds of Chinese materia medica,most of which were fewer than 12.High-frequency drugs included Glycyrrhizae Radix et Rhizoma,Pinelliae Rhizoma,Ginseng Radix et Rhizoma,Armeniacae Semen Amarum,Citri Reticulatae Pericarpium,Poria,Zingiberis Rhizoma Recens,Schisandrae Chinensis Fructus,etc.The drug property was mainly warm;the main tastes were pungent,bitter and sweet,which mainly belong to the lung and spleen meridians.The main categories of efficacy were phlegm resolving,cough relieving,and asthma relieving drugs,as well as deficiency tonifying drugs.The association rules resulted in a total of 2 combinations of 18 items,3combinations of 34 items,and 4 combinations of 3 items,most of which were combinations of drugs for invigorating the spleen,dispelling dampness,strengthening lung and resolving phlegm,with the core medicinal combination of modified Erchen Decoction at the same time.Clustering analysis identified 6 medicinal groups,which had the characteristics of clearing the lung and moistening the lung,regulating qi and strengthening the spleen,eliminating dampness and phlegm,and warming yang.Conclusion Before the Ming Dynasty,medical practitioners relatively simplified the prescriptions and medication for cough,with a focus on warming,suitable moistening and drying,and treating the lung and spleen together,emphasizing the regulation of qi and phlegm.

关 键 词：咳嗽病 医方类聚·咳嗽门 数据挖掘 用药规律 

分 类 号：R2-05[医药卫生—中医学] R256.1