靳三针疗法治疗痴呆Meta分析  

Jin's Three-Needle Therapy in the Treatment of Dementia:A Meta-analysis

作　　者：刘洁洁 唐纯志 LIU Jiejie;TANG Chunzhi(Acupuncture Rehabilitation of Clinical Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510006,China)

机构地区：[1]广州中医药大学针灸康复临床医学院,广东广州510006

出　　处：《中国中医药图书情报杂志》2024年第4期171-177,共7页Chinese Journal of Library and Information Science for Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(82174479)。

摘　　要：目的 基于Meta分析评估靳三针疗法治疗痴呆的临床疗效。方法 检索PubMed、Embase、Web of Science(WOS)核心合集、Cochrane Library、中国知识资源总库(CNKI)、中文科技期刊数据库(VIP)、中国学术期刊数据库(万方数据)、中国生物医学文献数据库(CBM),收集建库至2023年9月10日与靳三针疗法治疗痴呆相关临床随机对照试验(RCT),使用RevMan5.4软件进行Meta分析。结果 共纳入29篇RCTs,总样本量2 231例,其中有18项研究报告了临床总有效率,25项研究报告了简易智能状态检查量表(MMSE),13项研究报告了日常生活能力量表(ADL),7项研究报告了长谷川痴呆修改量表(HDS),6项研究报告了蒙特利尔认知评估量表(MoCA),5项研究报告了痴呆中医证候积分,4项研究报告了不良反应。Meta分析结果显示,靳三针疗法治疗痴呆总有效率[RR=1.24,95%CI(1.18,1.31),P<0.000 01]优于对照组;试验组MMSE评分[MD=3.48,95%CI (2.23,4.73),P<0.000 01]、ADL评分[MD=11.55,95%CI(10.14,12.96),P<0.000 01]、HDS评分[MD=1.91,95%CI(0.49,3.33),P=0.008]、MoCA评分[MD=2.54,95%CI (1.54,3.54),P<0.000 01]、痴呆中医证候积分[MD=2.28,95%CI(1.76,2.80),P<0.000 01]改善均优于对照组。结论 试验组治疗痴呆总有效率优于对照组,试验组在提高MMSE评分上优于对照组,且疗程在24 d时疗效最佳,靳三针联合药物治疗在提高ADL评分上最优,在改善MoCA、HDS评分和痴呆中医证候积分上试验组优于对照组,但仍需更多大样本、高质量的临床试验加以验证。Objective To evaluate the clinical efficacy of Jin's three-needle therapy for dementia based on Metaanalysis.Methods Clinical randomized controlled trials(RCTs) related to Jin's three-needle therapy for dementia were retrieved from PubMed,Embase,Web of Science,Cochrane Library,CNKI,VIP,Wanfang Data,China Biology Medicine(CBM) from the establishment of databases to 10th,September 2023.Meta-analysis was finally performed using the RevMan 5.4 software.Results A total of 29 RCTs were included,with a total sample size of 2 231 patients,among which 18 studies reported the clinical total effective rate,25 studies reported the minimum mental state examination(MMSE),13 studies reported the activity of daily living scale(ADL),and 7 studies reported the Hastgawa dementia scale(HDS),6 studies reported the Montreal cognitive assessment(MoCA),5 studies reported the TCM symptom score scale for dementia,and 4 studies reported adverse reactions.The results of Meta-analysis showed that the total effective rate [RR=1.24,95%CI(1.18,1.31),P<0.000 01] of Jin's three-needle for the treatment of dementia was better than that of the control group.In the experimental group,MMSE [MD=3.48,95%CI(2.23,4.73),P<0.000 01],ADL [MD=11.55,95%CI(10.14,12.96),P<0.000 01],HDS [MD=1.91,95%CI(0.49,3.33),P=0.008],MoCA [MD=2.54,95%CI(1.54,3.54),P<0.000 01],TCM symptom score scale for dementia [MD=2.28,95%CI(1.76,2.80),P<0.000 01] were better than the control group.Conclusion The clinical total effective rate of experiment group for dementia is better than that of the control group.The experiment group is better than the control group in improving MMSE score,and works best when the course of treatment is set for 24 days;the Jin's threeneedle combined with drug treatment has the best ADL score.Compared with the control group,experiment group is better in improving the scores of MoCA,HDS and TCM symptom score scale for dementia,but more large samples and high-quality clinical trials are still needed to verify it.

关 键 词：靳三针疗法 痴呆 META分析 临床随机对照试验 

分 类 号：R259[医药卫生—中西医结合] R245.3[医药卫生—中医内科学]