归脾汤加减联合穴位刺激治疗失眠心脾两虚证疗效及安全性Meta分析  

Meta-analysis on the Efficacy and Safety of Modified Guipi Decoction Combined with Acupoint Stimulation in the Treatment of Insomnia with Heart-spleen Deficiency Syndrome

作　　者：俞梦娇 赵瑞祺 林志美 林森 彭立生[1] YU Mengjiao;ZHAO Ruiqi;LIN Zhimei;LIN Sen;PENG Lisheng(The Fourth Clinical Medicine College of Guangzhou University of Chinese Medicine,Shenzhen Hospital of Traditional Chinese Medicine,Shenzhen 518000,China)

机构地区：[1]广州中医药大学第四临床医学院,深圳市中医院,广东深圳518000

出　　处：《中国中医药图书情报杂志》2024年第4期196-199,共4页Chinese Journal of Library and Information Science for Traditional Chinese Medicine

摘　　要：目的 系统评价归脾汤加减联合穴位刺激对失眠心脾两虚证的治疗效果及安全性。方法 计算机检索中国知识资源总库(CNKI)、中文科技期刊数据库(维普网)、中国学术期刊数据库(万方数据)、中国生物医学文献数据库(CBM)、Cochrane Library、PubMed和Embase建库至2023年6月12日归脾汤加减联合穴位刺激治疗失眠心脾两虚证的临床随机对照试验(RCTs)。使用Cochrane5.4偏倚风险评估工具进行文献质量评价,并使用RevMan5.4软件进行Meta分析。结果 共纳入9篇RCTs,总样本量685例,其中试验组344例、对照组341例。Meta分析结果显示:与对照组相比,归脾汤加减联合穴位刺激治疗失眠总有效率提高[RR=1.23,95%CI(1.15,1.31),P<0.000 01]、匹兹堡睡眠质量指数评分降低[RR=3.88,95%CI(1.89,5.87),P<0.000 1]、不良反应减少[RR=3.03,95%CI(1.80,5.12),P<0.000 1],差异有统计学意义。结论 归脾汤加减联合穴位刺激治疗失眠心脾两虚证的疗效优于对照组,且安全性较高,可减少不良反应发生,但需更多高质量的RCTs进行验证。Objective To systematically evaluate the therapeutic effect and safety of modified Guipi Decoction combined with acupoint stimulation for the treatment of insomnia with heart-spleen deficiency syndrome.Methods Literature related to clinical randomized controlled trials(RCTs) about modified Guipi Decoction combined with acupoint stimulation for the treatment of insomnia with heart-spleen deficiency syndrome was retrieved from CNKI,VIP,Wanfang Data,CBM,Cochrane Library,PubMed and Embase from the establishment of the databases to June 12,2023.Cochrane 5.4 biasrisk assessment tool was used for literature quality evaluation.Metaanalysis was perfprmed using RevMan 5.4 software.Results A total of 9 RCTs involving 685 patients were included of which 344 were in the trial group and 341 in the control group.Meta-analysis results showed that compared with the control group,the total effective rate of insomnia treatment with the combination of modified Guipi Decoction and acupoint stimulation increased [RR=1.23,95% CI(1.15,1.31),P<0.000 01],PSQI score decreased [RR=3.88,95%CI(1.89,5.87),P<0.000 1],and adverse reactions decreased [RR=3.03,95%CI(1.80,5.12),P<0.000 1],with statistical significance.Conclusion Modified Guipi Decoction combined with acupoint stimulation for the treatment of insomnia with heart-spleen deficiency syndrome is better than that of the control group,with higher safety,which can decreased the occurrence of adverse reactions,but more high-quality RCTs are needed for validation.

关 键 词：穴位刺激 失眠心脾两虚证 归脾汤 META分析 

分 类 号：R289.3[医药卫生—方剂学] R245.9[医药卫生—中药学]