中药及其有效成分防治绝经后骨质疏松症机制研究进展  

Research Progress in the Mechanism of Chinese Materia Medica and Its Active Components for the Treatment of Postmenopausal Osteoporosis

作　　者：朱康 李宏键[2] 陈会仙 向俊宜 保超宇[1,3] 卢钰 尹本敬 李具宝 ZHU Kang;LI Hongjian;CHEN Huixian;XIANG Junyi;BAO Chaoyu;LU Yu;YIN Benjing;LI Jubao(First Clinical Medical College,Yunnan University of Chinese Medicine,Kunming 650500,China;The First People’s Hospital of Yunnan Province,Kunming 650500,China;Yunnan Provincial Hospital of Traditional Chinese Medicine,Kunming 650021,China)

机构地区：[1]云南中医药大学第一临床医学院,云南昆明650500 [2]云南省第一人民医院,云南昆明650500 [3]云南省中医医院,云南昆明650021

出　　处：《中国中医药图书情报杂志》2024年第4期262-267,共6页Chinese Journal of Library and Information Science for Traditional Chinese Medicine

基　　金：国家自然科学基金地区科学基金(81860862);国家中医药管理局青年岐黄学者培养项目(2022年);云南省科技厅中青年学术和技术带头人后备人才及省级技术创新培养对象(2019年);云南省卫生健康委高层次中医药人才培养对象(2021年)。

摘　　要：绝经后骨质疏松症(PMOP)是绝经后女性骨骼系统代谢紊乱导致的疾病之一,发病期间易导致骨折,且存在治疗周期长、一线治疗药物不良反应多、迁延难愈、生活质量严重下降等问题,PMOP临床表现以腰背部及四肢多关节疼痛为主,偶伴随躯干畸形变、全身乏力、腹部不适等症状。本文主要阐述中药及其有效成分可通过调节信号通路、激活相关信号通路关键蛋白分子的表达,促进成骨细胞分化和成骨效应,抑制破骨细胞分化及其生物活性,抑制氧化应激和炎症反应,纠正铁过载,调节肠道菌群及发挥类雌激素效应,逆转骨微结构的破坏,提高骨密度、平衡骨稳态,达到改善骨代谢和免疫作用,进而发挥治疗PMOP的作用。为进一步深度开展中药及其有效成分治疗PMOP机制类研究提供参考。Postmenopausal osteoporosis(PMOP) is one of the diseases caused by metabolic disorders of the skeletal system in postmenopausal women,which is prone to fracture during the onset of the disease and is characterized by a long treatment period,side effects of the first-line therapeutic drugs,prolonged and difficult to recover,and a serious decline in the quality of life,etc.Clinical manifestations of PMOP are mainly pains of the lower back and multiple joints of the limbs,occasionally accompanied by deformity of the trunk,generalized fatigue,abdominal discomfort and other symptoms.This article mainly elaborated that Chinese materia medica and its active components can promote osteoblast differentiation and osteogenic effects by regulating signaling pathways and activating the expression of key protein molecules in related signaling pathways,correct iron overload,regulate the intestinal flora,and play the effect of oestrogen to reverse the destruction of bone microstructure,improve bone mineral density,and balance the homeostasis,so as to achieve the improvement of bone metabolism and immunity,and then play a role in the treatment of PMOP,which could provide a reference for further research on the mechanism of PMOP treatment by Chinese materia medica and its active components.

关 键 词：绝经后骨质疏松症 中药 有效成分 机制研究 综述 

分 类 号：R274.9[医药卫生—中西医结合]