衣物消毒剂引起的颗粒状角化不全四例  

Four cases of granular parakeratosis induced by disinfectants

作　　者：夏曼琪 邵蕾 周欣 梁毅敏 陈紫妍 黄琼霄 田歆 刘玉梅 XIA Manqi;SHAO Lei;ZHOU Xin;LIANG Yimin;CHEN Ziyan;HUANG Qiongxiao;TIAN Xin;LIU Yumei(Institute of Dermatology,Guangzhou Medical University,Guangzhou 510000,China;Guangzhou Dermatology Hospital,Guangzhou 510000,China;Guangdong Sian Hospital,Dongguan 523001,China)

机构地区：[1]广州医科大学皮肤病研究所,广东广州510000 [2]广州市皮肤病医院皮肤科,广东广州510000 [3]广东省泗安医院皮肤科,广东东莞523001

出　　处：《中国麻风皮肤病杂志》2024年第7期480-483,共4页China Journal of Leprosy and Skin Diseases

基　　金：广州市科技计划项目(编号:2023A03J0473);2021市卫生健康科技一般引导项目(编号:20211A011067)。

摘　　要：颗粒状角化不全较罕见,临床易误诊。本文报道衣物消毒剂引起的颗粒状角化不全4例,3例患者停止接触消毒剂、全身使用润肤剂后皮损消退,1例患者口服糖皮质激素后皮损明显改善。因此对于皮损表现为对称性红斑伴反复脱屑、呈羊皮纸样外观的患者,皮肤科医生应提高颗粒状角化不全的诊治意识,详细询问消毒剂接触史,指导患者及时停止接触消毒剂并使用润肤剂,必要时可考虑短期系统应用糖皮质激素。Granular parakeratosis(GP) is rare and easy to be misdiagnosed.We report 4 cases of granular GP caused by clothing disinfectant.The skin lesions of 3 patients subsided after stopping contact with disinfectants and systemic use of emollients,and 1 patient improved significantly after oral glucocorticoids.Dermatologists should strengthen the awareness of diagnosis and treatment of GP with symmetrically erythema with repeated desquamation,take a complete history of exposure to disinfectants,instruct patients to promptly stop using the disinfectants and consider short-term systemic use of glucocorticoids according to the condition.

关 键 词：颗粒状角化不全 消毒剂 

分 类 号：R751[医药卫生—皮肤病学与性病学]