JAK抑制剂在白癜风治疗中的应用进展  

Update of Janus kinase inhibitors in the treatment of vitiligo

作　　者：衍元元 赵艳霞[2] 成玉 YAN Yuanyuan;ZHAO Yanxia;CHENG Yu(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine,Tianjin 300120,China;Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China)

机构地区：[1]天津中医药大学,天津301617 [2]天津市中医药研究院附属医院,天津300120 [3]首都医科大学附属北京中医医院,北京100010

出　　处：《中国麻风皮肤病杂志》2024年第7期519-523,共5页China Journal of Leprosy and Skin Diseases

基　　金：国家自然科学基金资助(编号:82174380)。

摘　　要：近年来,较多研究表明Janus激酶-信号转导和转录激活因子(JAK-STAT)信号通路在白癜风免疫发病机制中起着重要作用,而基于此通路的Janus激酶(JAK)抑制剂,在白癜风治疗中显示出强大的治疗前景。文章对近几年JAK抑制剂在白癜风中的作用机制、临床疗效和安全性等方面的研究进展进行了综述。In recent years,more studies have shown that JAK-STAT signaling pathway plays an important role in the immune pathogenesis of vitiligo,and JAK inhibitors based on this pathway have shown a strong therapeutic prospect in the treatment of vitiligo.The update of the mechanism,clinical efficacy and safety of JAK inhibitors of vitiligo in recent years are reviewed in this paper.

关 键 词：白癜风 JAK-STAT信号通路 JAK抑制剂 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]