射频联合外用药物在增生性瘢痕治疗中的应用  

Radiofrequency Combined with Topical Drugs in the Treatment of Hyperplastic Scars

作　　者：张杉 杨亦 付秋悦 陈浩 熊楚楚 张天琦 胡国强(综述) 陈刚(审校)[1] ZHANG Shan;YANG Yi;FU Qiuyue;CHEN Hao;XIONG Chuchu;ZHANG Tianqi;HU Guoqiang;CHEN Gang(Department of Plastic Surgery,Jiangsu Province Hospital of Traditional Chinese Medicine,Nanjing 210029,Jiangsu,China;Department of Plastic Surgery,Air Force Hospital of Eastern Theater Command of Chinese PLA,Nanjing 210002,Jiangsu,China)

机构地区：[1]南京中医药大学附属医院(江苏省中医院)整形外科,江苏南京210029 [2]中国人民解放军东部战区空军医院烧伤整形外科,江苏南京210002

出　　处：《中国美容医学》2024年第6期185-188,共4页Chinese Journal of Aesthetic Medicine

摘　　要：瘢痕是人体创伤修复的必然产物,其治疗方式有多种,包括药物、光电、手术治疗等。常见的外用抗瘢痕药物包括硅酮凝胶、植物提取物等,但局部外用抗瘢痕药物受到皮肤屏障的限制,渗透效率低。射频是由电磁辐射产生的电流,当射频作用于皮肤时产生热效应可刺激胶原蛋白合成和重塑,从而有效防治增生性瘢痕。射频也是一种物理促透方法,通过产生皮下微通道输送药物,提高了药物的经皮吸收。该文对常见的外用抗瘢痕药物及其机制、射频技术的发展及射频联合药物在增生性瘢痕治疗中的应用进行了分析和总结,有助于进一步扩展增生性瘢痕的临床治疗思路,提高其治疗效果。Scars occur after human trauma repair and the treatment of hypertrophic scar is still a hot and difficult problem.Treatments for scarring include medications,photovoltaic,and surgical therapies.Common anti-scar drugs include silicone gel,plant extracts.However local topical anti-scar medication shows low penetration efficiency because of the limitation of skin barrier.Radiofrequency(RF)is an electrical current generated by electromagnetic radiation.RF produces a thermal effect that can stimulate the synthesis and remodeling of collagen,which can be an effective prevention and treatment of hypertrophic scar.It is also a physical penetration method,which acts on the skin to produce subcutaneous microchannels,thus improving the percutaneous absorption of the drug.In this paper,the common topical anti-scar drugs and their mechanisms,the development of radiofrequency technology and the application of radiofrequency combined drugs in scar treatment were analyzed and summarized,which will help to further expand the clinical treatment of hypertrophic scar and improve its therapeutic effect.

关 键 词：射频 增生性瘢痕 硅酮 积雪苷 洋葱提取物 

分 类 号：R619.6[医药卫生—外科学]