半乳糖凝集素3在糖尿病视网膜病变发生发展中的作用  

Research progress of galactose lectin 3 in diabetes retinopathy

作　　者：冯兆琛 周子义 孙小佳 窦国睿 Feng Zhaochen;Zhou Ziyi;Sun Xiaojia;Dou Guorui(Department of Ophthalmology,Xijing Hospital,Air Force Medical University,Eye Institute of PLA,Xi’an 710032,China;School of Basic Medicine,Air Force Medical University,Xi’an 710032,China)

机构地区：[1]空军军医大学西京医院眼科、全军眼科研究所,西安710032 [2]空军军医大学基础医学院,西安710032

出　　处：《国际眼科纵览》2024年第2期116-122,共7页International Review of Ophthalmology

基　　金：国家自然科学基金(82371071,81970814)。

摘　　要：在糖尿病视网膜病变(diabetic retinopathy,DR)的病理变化中,慢性炎症、血管生成和渗漏、免疫细胞激活等机制发挥着重要作用.半乳糖凝集素3(galectin-3,Gal-3)是半乳糖凝集素家族中唯一的嵌合型成员,被证明与疾病的炎症、细胞黏附和趋化相关.Gal-3通过调节视网膜中的小胶质细胞、巨噬细胞等免疫细胞的表型、吞噬能力、趋化状态,调控DR中炎症的进展;也可作用于血管内皮细胞、视网膜色素上皮细胞和周细胞,对血-视网膜屏障产生影响.此外,Gal-3已被证实可以作为疾病标志物和治疗靶点,并可以作为重要的预后评估指标.目前,Gal-3已作为治疗靶点在多种涉及全身炎症和血管性疾病中显示出安全性和有效性,Gal-3抑制剂的应用也为糖尿病视网膜病变提供了尤其是在减轻病理性新生血管方面的治疗思路.通过对Gal-3的研究对于理解DR的发病机制和探索其新的治疗方式具有重要意义.In the pathological changes of diabetic retinopathy(DR),chronic inflammation,vascular regeneration and leakage,and immune cell activation play important roles.Galectin-3(Gal-3)is the only chimeric member of the galectin family,proven to be associated with disease inflammation,cell adhesion,and chemotaxis.Gal-3 regulates the phenotype,phagocytic ability,and chemotaxis of immune cells such as microglia and macrophages in the retina,modulating the progression of inflammation in DR.It can also act on vascular endothelial cells,retinal pigment epithelial cells,and pericytes,affecting the blood-retinal barrier.Furthermore,Gal-3 has been confirmed as a disease marker and therapeutic target,serving as an important prognostic evaluation indicator.Currently,Gal-3 has demonstrated safety and efficacy as a therapeutic target in various systemic inflammatory and vascular diseases,and the use of Gal-3 inhibitors has provided a therapeutic approach,especially in alleviating pathological neovascularization in diabetic retinopathy.Research on Gal-3 is of great significance for understanding the pathogenesis of DR and exploring new treatment approaches.

关 键 词：半乳糖凝集素3 糖尿病视网膜病变 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]