创伤性肋骨骨折患者血清SP-D和sVCAM-1水平改变与其术后骨折愈合及短期预后的关系  

Relationship between changes in serum SP-D and sVCAM-1 levels and postoperative fracture healing and short-term prognosis in patients with traumatic rib fractures

作　　者：张飞越 冉隆强 李勇[1] 贾鹏 罗欢 汪小华 ZHANG Feiyue;RAN Longqiang;LI Yong;JIA Peng;LUO Huan;WANG Xiaohua(Department of Emergency,Banan Hospital Affiliated to Chongqing Medical University,Chongqing 401320,China;Department of Orthopedics,the First Affiliated Hospital of Army Medical University,Chongqing 400038,China)

机构地区：[1]重庆医科大学附属巴南医院急救部,重庆401320 [2]陆军军医大学附属第一医院骨科,重庆400038

出　　处：《国际检验医学杂志》2024年第11期1281-1284,1288,共5页International Journal of Laboratory Medicine

基　　金：国家自然科学基金项目(82202707)。

摘　　要：目的探讨创伤性肋骨骨折患者血清人表面活性蛋白D(SP-D)和血管细胞黏附分子-1(sVCAM-1)水平改变与其术后骨折愈合及短期预后的关系。方法选取2020年1月至2021年12月于重庆医科大学附属巴南医院就诊并进行治疗的创伤性肋骨骨折患者102例作为研究对象,在对患者治疗8个月后,及时对患者的愈合情况进行分析并分组,其中不愈合组21例,愈合组81例。根据患者的肺挫伤情况,将其分为肺挫伤组19例,非肺挫伤组83例。分别比较愈合组及不愈合组、肺挫伤组及非肺挫伤组患者的血清SP-D和sVCAM-1水平,研究创伤性肋骨骨折患者血清SP-D和sVCAM-1水平改变与其术后骨折愈合及短期预后的关系。结果愈合组SP-D和sVCAM-1水平低于不愈合组(P<0.05),非肺挫伤组SP-D和sVCAM-1水平低于肺挫伤组(P<0.05),血清SP-D和sVCAM-1水平为患者术后骨折愈合及短期预后的独立危险因素。结论创伤性肋骨骨折患者血清SP-D和sVCAM-1水平改变与其术后骨折愈合及短期预后有关,可作为预后判定的重要参考。Objective To investigate the relationship between the changes of serum human surfactant protein D(SP-D)and vascular cell adhesion molecule-1(sVCAM-1)levels and postoperative fracture healing and short-term prognosis in patients with traumatic rib fractures.Methods A total of 102 patients with traumatic rib fractures who were treated in Banan Hospital Affiliated to Chongqing Medical University from January 2020 to December 2021 were selected as the research objects.After 8 months of treatment,the healing status of the patients was analyzed and divided into non-healing group(21 cases)and healing group(81 cases).According to the pulmonary contusion,the patients were divided into pulmonary contusion group(19 cases)and non-pulmonary contusion group(83 cases).The serum levels of SP-D and sVCAM-1 were compared between the healing group and the non-healing group,and between the pulmonary contusion group and the non-pulmonary contusion group.The relationship between the changes of serum SP-D and sVCAM-1 levels and postoperative fracture healing and short-term prognosis in patients with traumatic rib fractures were studied.Results The levels of SP-D and sVCAM-1 in the healing group were lower than those in the non-healing group(P<0.05).The levels of SP-D and sVCAM-1 in the non-pulmonary contusion group were lower than those in the pulmonary contusion group(P<0.05).Serum SP-D and sVCAM-1 levels were independent risk factors for postoperative fracture healing and short-term prognosis.Conclusion The changes of serum SP-D and sVCAM-1 levels in patients with traumatic rib fractures are related to fracture healing and short-term prognosis,which can be used as an important reference for prognosis evaluation.

关 键 词：创伤性肋骨骨折 人表面活性蛋白D 血管细胞黏附分子-1 

分 类 号：R641[医药卫生—外科学]