中药浸浴联合重组表皮细胞在压疮患者中的应用效果  

Application effect of traditional Chinese medicine soaking combined with recombinant epidermal cells in pressure ulcer patients

作　　者：颜廷荣 程小平 高明龙 陈黎明 李雪红 毛智 YAN Tingrong;CHENG Xiaoping;GAO Minglong;CHEN Liming;LI Xuehong;MAO Zhi(Department of Nursing,Guixi Traditional Chinese Medicine Hospital,Jiangxi Province,Guixi 335400,China)

机构地区：[1]江西省贵溪市中医院护理部,江西贵溪335400

出　　处：《中国当代医药》2024年第15期90-93,98,共5页China Modern Medicine

基　　金：江西省中医药管理局科技计划项目(2023B0980)。

摘　　要：目的探究中药浸浴联合重组表皮细胞在压疮患者中的应用效果。方法选取2022年1月至2023年6月贵溪市中医院收治的60例压疮患者作为研究对象,采用随机数字表法将其分为对照组与观察组,每组各30例。对照组采用重组表皮细胞生长因子方法,观察组在对照组基础上使用中药浸浴,分析两组干预后的创面愈合有效率、炎症因子水平、症状缓解时间、转化生长因子(TGF-β1)、血管内皮生长因子(VEGF)表达水平以及不良反应发生率。结果治疗前两组的TGF-β1、VEGF表达水平、炎症因子水平比较,差异无统计学意义(P>0.05)。观察组治疗后TGF-β1、VEGF表达水平以及炎症因子水平均低于对照组,差异有统计学意义(P<0.05)。观察组症状缓解时间、不良反应发生率低于对照组,差异有统计学意义(P<0.05)。观察组创面愈合总有效率高于对照组,差异有统计学意义(P<0.05)。结论在临床上对压疮创面修复中采用重组表皮细胞生长因子联合中药浸浴效果更好,患者创面愈合有效率提高,症状缓解时间缩短,不良反应发生率少,安全性高且效果显著,临床应用价值高。Objective To explore the application effect of traditional Chinese medicine soaking combined with recombinant epidermal cells in patients with pressure ulcers.Methods Sixty patients with pressure ulcers admitted to Guixi Traditional Chinese Medicine Hospital from January 2022 to June 2023 were selected as the study subjects.They were divided into control group and observation group using the random number table method,with 30 cases in each group.The control group was treated with recombinant epidermal growth factor method,while the observation group was treated with traditional Chinese medicine soaking on the basis of the control group.The effective rate of wound healing,inflammatory factor levels,symptom relief time,and transforming growth factor-β1(TGF-β1)of the two groups after intervention were analyzed.The expression level of vascular endothelial growth factor(VEGF)and the incidence of adverse reactions.Results The comparison of TGF-β1,VEGF expression level and inflammatory factor level of the two group before treatment showed no statistically significant differences(P>0.05).After treatment,the expression levels of TGF-β1,VEGF and inflammatory factors of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).The symptom relief time and incidence of adverse reactions in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate of wound healing in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion In clinical practice,the use of recombinant epidermal growth factor combined with traditional Chinese medicine soaking is more effective in repairing pressure ulcer wounds.The total effective rate of wound healing in patients is improved,the time for symptom relief is shortened,the incidence of adverse reactions is low,the safety is high,and the effect is significant.The clini

关 键 词：重组表皮细胞生长因子 中药浸浴 压疮 症状缓解时间 创面愈合有效率 

分 类 号：R26[医药卫生—中医外科学]