1例碳青霉烯耐药产气肠杆菌颅内感染患者的药学监护  

Pharmaceutical care of a patient with intracranial infection of carbapenem-resistant enterobacter aerogenes

作　　者：林辉国 谭红平 苏方华 LIN Huiguo;TAN Hongping;SU Fanghua(Department of Pharmacy,Guangdong Sanjiu Brain Hospital,Guangdong Province,Guangzhou 510510,China;Department of Neurosurgery,Guangdong Sanjiu Brain Hospital,Guangdong Province,Guangzhou 510510,China)

机构地区：[1]广东三九脑科医院药剂科,广东广州510510 [2]广东三九脑科医院神经外科,广东广州510510

出　　处：《中国当代医药》2024年第15期138-143,共6页China Modern Medicine

摘　　要：颅内感染是神经外科术后常见严重并发症。临床药师通过参与1例神经外科手术后继发碳青霉烯耐药产气肠杆菌颅内感染患者的抗感染治疗全过程,分析抗感染治疗用药的合理性和提出用药建议,并进行针对性药学监护。临床药师紧密结合患者病情特点及变化情况,根据抗菌药物药代动力学/药效学理论协助临床医生制定个体化抗感染治疗方案,通过延长美罗培南滴注时间联合静脉滴注阿米卡星并鞘内注射以及序贯左氧氟沙星治疗方案以及外科清创引流等方法,成功治愈碳青霉烯耐药产气肠杆菌颅内感染患者,体现临床药师在颅内感染临床治疗中的价值。Intracranial infection is a common serious complication after neurosurgery.Clinical pharmacists participated in the whole process of anti-infective treatment of a patient with intracranial infection of carbapenem-resistant enterobacter aerogenes after neurosurgery,analyzed the rationality of anti-infective treatment drugs,put forward medication suggestions,and conducted targeted pharmaceutical care.Clinical pharmacists closely combine the characteristics and changes of the patient's condition,and assist clinicians in formulating an individualized anti-infection treatment plan according to the pharmacokinetic/pharmacodynamic theory of antibacterial drugs.By extending the infusion time of Meropenem combined with intravenous Amikacin and intrathecal injection,sequential Levofloxacin treatment plan,surgical debridement and drainage,etc.The successful treatment of intracranial infection of carbapenem-resistant enterobacter aerogenes reflects the value of clinical pharmacists in the clinical treatment of intracranial infection.

关 键 词：碳青霉烯耐药 产气肠杆菌 颅内感染 药学监护 

分 类 号：R378[医药卫生—病原生物学]