线粒体靶向的罗丹明衍生物用于肿瘤荧光成像  

Mitochondria-targeted rhodamine photosensitizers for tumor fluorescence imaging

作　　者：王书鹏 杜健军[1,2] 姚瑶 樊江莉[1,2] 彭孝军[1] WANG Shupeng;DU Jianjun;YAO Yao;FAN Jiangli;PENG Xiaojun(State Key Laboratory of Fine Chemicals,Frontiers Science Center for Smart Materials Oriented Chemical Engineering,Dalian University of Technology,Dalian 116024,Liaoning,China;Ningbo Institute of Dalian University of Technology,Ningbo 315016,Zhejiang,China)

机构地区：[1]大连理工大学精细化工国家重点实验室,智能材料导向化学工程前沿科学中心,辽宁大连116024 [2]大连理工大学宁波研究院,浙江宁波315016

出　　处：《化工学报》2024年第4期1679-1686,共8页CIESC Journal

基　　金：国家自然科学基金项目(21925802,22090011,22338005);辽宁滨海实验室项目(LBLB-2023-03);中央高校基本科研业务费专项(CDUTZZLAB601,DUT23YG137)。

摘　　要：设计合成了两例以罗丹明为母体的荧光染料RDMID-C和RDMID-N。实验结果表明,上述染料分子具有较低的细胞毒性,良好的生物相容性及靶向细胞线粒体的能力。两例荧光染料在细胞器定位实验中与商业化线粒体染料的共定位系数较高,并在小鼠肿瘤中有较长的滞留时间,可以用于肿瘤荧光成像。Two examples of fluorescent dyes RDMID-C and RDMID-N using rhodamine as the parent were designed and synthesized.The results showed that the dyes exhibited low cytotoxicity,good biocompatibility,and the ability to target mitochondria.The fluorescence dyes showed higher co-localization coefficient with commercial mitochondrial dyes in co-localization experiments,and had longer retention time in tumors,which could be used for tumor fluorescence imaging.

关 键 词：染料 荧光成像 生物医学工程 生物工程 生物技术 

分 类 号：TQ617.3[化学工程—精细化工]