Notch信号通路与先天性心脏病  

Notch Signaling Pathway and Congenital Heart Disease

作　　者：田坤灵 陈川宁 TIAN Kuning;CHEN Chuanning(Clinical Medical College 2Department of Biochemistry and Molecular Biology,Southwest Medical University,Luzhou,Sichuan 646000,China)

机构地区：[1]西南医科大学临床医学院,四川泸州646000 [2]西南医科大学基础医学院生物化学与分子生物学教研室,四川泸州646000

出　　处：《协和医学杂志》2024年第3期649-654,共6页Medical Journal of Peking Union Medical College Hospital

基　　金：四川省省级大学生创新创业训练计划(S202210632319)。

摘　　要：先天性心脏病(congenital heart disease, CHD)指胎儿在胚胎时期的心脏发育异常,通常伴有大血管发育不良,其发病机制复杂,目前尚未阐明。研究表明,Notch信号通路参与心脏发育的全过程,包括原始心脏的形成及发育、出生后心脏正常功能的维持,该通路异常会导致CHD的发生。本文就Notch信号通路参与心脏生长发育以及导致CHD的作用机制展开综述,以期为CHD的早期诊断提供参考。Congenital heart disease(CHD)refers to abnormal development of the heart in the foetus during the embryonic period,usually accompanied by abnormal development of the large blood vessels.The pathogenesis of CHD is complex and has not yet been elucidated.Studies have shown that the Notch signaling pathway is involved in the whole process of cardiac development,including the formation and development of the primitive heart,and the maintenance of normal cardiac function after birth,and the abnormalities in this pathway can lead to the development of CHD.In this paper,we review the mechanisms of Notch signaling path-way involved in cardiac growth and development,with a view of providing reference for the early diagnosis of CHD.

关 键 词：先天性心脏病 NOTCH信号通路 心脏发育 

分 类 号：R541.1[医药卫生—心血管疾病] R364[医药卫生—内科学]