盐酸氨溴索注射液联合小剂量乳糖酸红霉素治疗小儿支气管肺炎的效果  

Effectiveness of Ambroxol Hydrochloride Injection Combined with Small-dose Erythromycin Lactobionate in the Treatment of Pediatric Bronchopneumonia

作　　者：杨乾 Yang Qian(Hefei Maternal and Child Health Hospital(Anhui Women and Children's Medical Center),Hefei 230001,Anhui Province,China)

机构地区：[1]合肥市妇幼保健院(安徽省妇女儿童医学中心),安徽合肥230001

出　　处：《中外医药研究》2024年第11期39-41,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:探讨盐酸氨溴索注射液联合小剂量乳糖酸红霉素治疗小儿支气管肺炎的效果。方法:选取2021年6月—2023年6月合肥市妇幼保健院收治的82例支气管肺炎患儿为研究对象,随机分为对照组和观察组,各41例。对照组采用盐酸氨溴索注射液治疗,观察组采用盐酸氨溴索注射液联合小剂量乳糖酸红霉素治疗。比较两组肺功能、症状消失时间、住院时间、不良反应发生率。结果:治疗前,两组第1秒用力呼气容积(FEV_(1)),FEV_(1)占预计值的百分比(FEV_(1)%)比较,差异无统计学意义(P>0.05);治疗后,两组FEV_(1)、FEV_(1)%升高,观察组高于对照组,差异有统计学意义(P<0.05)。观察组气促、发热、咳嗽、肺部啰音消失时间及住院时间均短于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:盐酸氨溴索注射液联合小剂量乳糖酸红霉素治疗小儿支气管肺炎的效果较好,能改善肺部功能,促进各项症状消失,安全性高。Objective:To investigate the effect of ambroxol hydrochloride injection combined with small-dose erythromycin lactobionate in the treatment of pediatric bronchopneumonia.Methods:Eighty-two cases of children with bronchopneumonia admitted to Hefei Maternal and Child Health Hospital from June 2021 to June 2023 were selected as the study subjects,and randomly divided into the control group and the observation group,each with forty-one cases.The control group was treated with ambroxol hydrochloride injection,and the observation group was treated with ambroxol hydrochloride injection combined with small-dose erythromycin lactobionate.Lung function,symptom disappearance time,hospitalization time,and incidence of adverse reactions were compared between the two groups.Results:Before treatment,the comparison of forced expiratory volume in one second(FEV_(1)),FEV_(1) as a percentage of the expected value(FEV_(1)%)between the two groups,the difference was not statistically significant(P>0.05);after treatment,the FEV_(1),FEV_(1)%of the two groups were elevated,and the observation group was higher than the control group,and the difference was statistically significant(P<0.05).Shortness of breath,fever,cough and lung rales disappearing time and hospitalization time of the observation group were shorter than that of the control group,and the difference was statistically significant(P<0.05).Comparison of the incidence rate of adverse reactions between the two groups,the difference was not statistically significant(P>0.05).Conclusion:Ambroxol hydrochloride injection combined with small-dose erythromycin lactobionate is more effective in the treatment of pediatric bronchopneumonia,which can improve the lung function and promote the disappearance of various symptoms,with high safety.

关 键 词：盐酸氨溴索 乳糖酸红霉素 小儿支气管肺炎 肺功能 

分 类 号：R725.6[医药卫生—儿科]