利福平联合盐酸乙胺丁醇治疗肺结核的效果分析  

Effect Analysis of Rifampicin Combined with Ethambutol Hydrochloride in the Treatment of Pulmonary Tuberculosis

作　　者：陈龙 Chen Long(GuiyangPublicHealthTreatmentCenter,Guiyang 550001,GuizhouProvince,China)

机构地区：[1]贵阳市公共卫生救治中心,贵州贵阳550001

出　　处：《中外医药研究》2024年第11期57-59,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:分析利福平联合盐酸乙胺丁醇治疗肺结核的效果。方法:选取2023年1月—2024年1月贵阳市公共卫生救治中心收治的肺结核患者70例作为研究对象,通过随机数字表法分为对照组和观察组,各35例。对照组采用盐酸乙胺丁醇治疗,观察组采用利福平联合盐酸乙胺丁醇治疗。比较两组肺功能[最大呼气中段流量(MMF)、用力肺活量(FVC)],基质金属蛋白酶9(MMP-9)、肺腺癌转移相关转录因子1(MALAT1)水平,临床疗效,不良反应发生率。结果:治疗前,两组MMF、FVC水平比较,差异无统计学意义(P>0.05);治疗后,两组MMF、FVC水平升高,观察组高于对照组,差异有统计学意义(P<0.05)。治疗前,两组MMP-9、MALAT1水平比较,差异无统计学意义(P>0.05);治疗后,两组MMP-9、MALAT1水平降低,观察组低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P=0.032)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:利福平联合盐酸乙胺丁醇治疗肺结核的效果、安全性较好,能改善患者的肺功能,降低MMP-9、MALAT1水平。Objective:To analyze the effect of rifampicin combined with ethambutol hydrochloride on pulmonary tuberculosis.Methods:A total of seventy tuberculosis patients admitted to Guiyang Public Health Treatment Center from January 2023 to January 2024 were selected as the research objects,and were divided into control group and observation group by random number table method,with thirty-five cases in each group.The control group was treated with ethambutol hydrochloride,and the observation group was treated with rifampicin combined with ethambutol hydrochloride.The levels of lung function[maximum mid-expiratory flow(MMF),forced vital capacity(FVC)],matrix metalloproteinase-9(MMP-9),metastasis-associated lung adenocarcinoma transcript 1(MALAT1),clinical efficacy and incidence of adverse reactions were compared between the two groups.Results:Before treatment,there was no significant difference in MMF and FVC levels between the two groups(P>0.05);after treatment,MMF and FVC levels in the two groups were increased,and the observation group was higher than the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in MMP-9 and MALAT1 levels between the two groups(P>0.05);after treatment,the levels of MMP-9 and MALAT1 in two groups were decreased,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P=0.032).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Rifampicin combined with ethambutol hydrochloride has good efficacy and safety in the treatment of pulmonary tuberculosis,which can improve the lung function of patients and reduce the level of MMP-9 and MALAT1.

关 键 词：肺结核 盐酸乙胺丁醇 利福平 基质金属蛋白酶9 肺腺癌转移相关转录因子1 

分 类 号：R251[医药卫生—中医内科学]