天王补心汤加减治疗心阴不足型不寐的临床效果  

Clinical Effect of Tianwang Buxin Decoction Plus Reduction in Treating Heart-Yin Insufficiency Type of Insomnia

作　　者：果春雨 Guo Chunyu(Department of Traditional Chinese Medicine,Beijing Haidian District Huayuan Road Community Health Center,Beijing 100088,China)

机构地区：[1]北京市海淀区花园路社区卫生服务中心中医科,北京100088

出　　处：《中外医药研究》2024年第11期91-93,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:研究天王补心汤加减治疗心阴不足型不寐的临床效果。方法:选取2022年7月—2023年7月北京市海淀区花园路社区卫生服务中心中医科收治的心阴不足型不寐患者78例为研究对象,随机分为对照组和观察组,各39例。对照组以常规西药治疗,观察组以天王补心汤加减治疗。比较两组中医证候积分、临床疗效、睡眠质量、神经递质水平。结果:治疗后,两组彻夜不寐、寐而易醒、五心烦热评分降低,观察组低于对照组,差异有统计学意义(P<0.05);观察组总有效率高于对照组,差异有统计学意义(P=0.033);治疗后,两组睡眠潜伏期、快速动眼睡眠时间缩短,睡眠总时间延长,匹兹堡睡眠质量指数(PSQI)评分降低,观察组睡眠潜伏期、快速动眼睡眠时间短于对照组,睡眠总时间长于对照组,PSQI评分低于对照组,差异有统计学意义(P<0.05);治疗后,两组5-羟色胺(5-HT)、多巴胺(DA)水平降低,γ-氨基丁酸(GABA)水平升高,观察组5-HT、DA水平低于对照组,GABA水平高于对照组,差异有统计学意义(P<0.05)。结论:天王补心汤加减治疗心阴不足型不寐有良好效果,可减轻中医证候,提高睡眠质量,改善神经递质水平。Objective:To study the clinical effect of Tianwang Buxin decoction plus reduction in the treatment of heart-Yin insufficiency type of insomnia.Methods:Selected seventy-eight patients with heart-Yin insufficiency type of insomnia admitted to the Department of Traditional Chinese Medicine of Beijing Haidian District Huayuan Road Community Health Center from July 2022 to July 2023,and randomly divided them into the control group and the observation group,with thirty-nine cases in each group.The control group was treated with conventional western medicines,and the observation group was treated with Tianwang Buxin decoction plus reduction.The two groups were compared in terms of traditional Chinese medicine evidence points,clinical efficacy,sleep quality,neurotransmitter level.Results:After treatment,the scores of all-night sleeplessness,easy to wake up after sleep,and sphoria with feverish sensation in chest,palms and soles were reduced in the two groups,and the observation group was lower than the control group,with a statistically significant difference(P<0.05);the total effective rate of the observation group was higher than that of the control group,with a statistically significant difference(P=0.033);after treatment,the sleep latency and rapid eye movement sleep time of the two groups were shortened,the total sleep time was prolonged,and the Pittsburgh Sleep Quality Index(PSQI)score was reduced;the sleep latency and rapid eye movement sleep time of the observation group was shorter than that of the control group,the total sleep time was longer than that of the control group,and the PSQI score was lower than that of the control group,and the difference was statistically significant(P<0.05);after treatment,the levels of 5-hydroxytryptamine(5-HT)and dopamine(DA)decreased and the level ofγ-aminobutyric acid(GABA)increased in the two groups,and the levels of 5-HT and DA in the observation group were lower than those in the control group and the level of GABA was higher than that in the control group,the difference w

关 键 词：不寐 心阴不足型 天王补心汤 睡眠质量 神经递质 

分 类 号：R256.23[医药卫生—中医内科学]