不同性别糖尿病患者饮食质量评分与全因病死率的关系  

Relationship between diet quality scores and all-cause mortality in diabetic patients of different genders

作　　者：刘畅[1] 信中[1] 杨金奎[1,2] Liu Chang;Xin Zhong;Yang Jinkui(Department of Endocrinology,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China;Beijing Diabetes Research Institute,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院内分泌科,北京100730 [2]北京市糖尿病研究所,北京100730

出　　处：《首都医科大学学报》2024年第3期406-412,共7页Journal of Capital Medical University

基　　金：国家自然科学基金项目(81400824)。

摘　　要：目的横断面研究不同性别的糖尿病患者多种饮食模式对全因死亡的影响和差异。方法分析来自美国国家健康和营养检查调查(National Health and Nutrition Examination Survey,NHANES)数据库中20002名参与者(3737名糖尿病患者)。用COX比例风险回归模型分析饮食质量评分与不同性别糖尿病患者全因死亡的关系。分层分析评估其他因素是否与饮食模式评分有相互作用。结果在74个月的中位随访期内,有512例死亡记录,男性311例,女性201例。饮食评分较高的糖尿病患者组对比较低组调整风险比如下:饮食炎症指数[男性:风险比(hazard ratio,HR)=1.22,P=0.084;女性HR=1.00,P=0.818];地中海饮食评分(男性:HR=0.99,P=0.873;女性HR=0.79,P=0.027);健康饮食指数-2020(男性HR=1.00,P=0.956;女性HR=0.83,P=0.046)。饮食评分对糖尿病患者死亡风险的影响是独立的,未发现饮食评分与其他变量存在内在的相互作用。结论糖尿病人群中,地中海饮食和健康饮食指数-2020与女性较低的死亡风险相关,而在男性未发现明显的关联。Objective To prospectively study the influence and difference of various dietary patterns on all-cause mortality in diabetes patients of different genders.Methods A total of 20002 participants(3737 patients with diabetes)from National Health and Nutrition Examination Survey(NHANES)were enrolled.The relationship between dietary quality score and all-cause mortality was analyzed with COX proportional hazards regression model,and whether other factors interact with dietary pattern scores was evaluated with the method of stratified analysis.Results During the median follow-up period of 74 months,there were 512 deaths recorded,with 311 males and 201 females.The adjusted risk ratios for high dietary quality are as follows:dietary inflammation index[male:hazard ratio(HR)=1.22,P=0.084;female:HR=1.00,P=0.818],mediterranean diet score(male:HR=0.99,P=0.873;female:HR=0.79,P=0.027),healthy diet index 2020(male:HR=1.00,P=0.956;female:HR=0.83,P=0.046).The influence of diet score on the death risk of diabetes patients is independent,and no internal interaction between diet score and other variables was found.Conclusion In the population with diabetes,mediterranean diet and healthy diet index 2020 are associated with lower mortality risk in women,while no significant association is found in men.

关 键 词：饮食质量评分 全因死亡 糖尿病 

分 类 号：R587.1[医药卫生—内分泌]