氟化胺牙膏对牙釉质再矿化效果研究  

Study on the enamel remineralization effect of amine fluoride toothpaste

作　　者：王婉 戴娇玉 岳红雷 潘晨倩 李雅倩 许少鹏 WANG Wan;DAI Jiao-yu;YUE Hong-ei;PAN Chen-qian;LI Ya-qian;XU Shao-peng(Dental Medical Devices Testing Center,Peking University School and Hospital of Stomatology,Beijing 100081,China;Colgate-Palmolive(China)Co.,Ltd.,Guangzhou,Guangdong 510623,China)

机构地区：[1]北京大学口腔医学院口腔医疗器械检验中心,北京100081 [2]高露洁棕榄(中国)有限公司,广东广州510730

出　　处：《日用化学品科学》2024年第6期60-63,共4页Detergent & Cosmetics

摘　　要：通过测试牙釉质中氟化物附着、牙釉质显微硬度变化以及抵抗酸蚀溶解效果,研究了氟化胺牙膏的生物利用度和体外再矿化效果。结果表明,和普通氟化钠牙膏相比,氟化胺牙膏可以更有效提高氟化物在牙釉质中的附着,显著提升牙釉质显微硬度,并减少牙釉质的酸蚀溶解(p<0.05),促进早期龋损再矿化。有机氟化胺活性分子兼具氟离子和有机胺双功能团,能提升氟离子生物利用度,高效递送氟离子至牙釉质表面并促进再矿化,发挥更好的防龋功效。The bioavailability and in vitro remineralization effect of amine fluoride toothpaste were studied by measuring the enamel fluoride uptake,enamel microhardness changes,and resistance to acid dissolution.The results show that compared with normal sodium fluoride toothpaste,amine fluoride toothpaste can more effectively improve the enamel fluoride uptake,significantly enhance enamel micro-hardness,reduce enamel acid dissolution(p<0.05),and promote early caries remineralization.Organic amine fluorite molecules possess dual functional groups of fluoride ions and organic amines,which can enhance the bioavailability of fluoride ions,efficiently deliver fluoride ions to the surface of enamel,and promote remineralization to exert better caries prevention effects.

关 键 词：有机氟 氟化胺 牙膏 牙釉质 再矿化 

分 类 号：TQ658[化学工程—精细化工]