黄杉素药理学基础及生物合成研究进展  

Advances in pharmacology and biosynthesis of taxifolin

作　　者：杨瑾冬 孙流畅 冯茜元 陈瑞兵 张磊 YANG Jin-dong;SUN Liu-chang;FENG Xi-yuan;CHEN Rui-bing;ZHANG Lei

机构地区：[1]海军军医大学药学院药用植物学教研室,上海200433

出　　处：《中国医药生物技术》2024年第3期214-222,共9页Chinese Medicinal Biotechnology

基　　金：国家自然科学基金(32170274、82225047);国家重点研发计划(2022YFC3501703、2023YFC3504800);上海市“科技创新行动计划”启明星项目(23QA1411400)。

摘　　要：黄杉素是一种二氢黄酮醇类活性天然产物,具有多种显著的药理活性,包括抗氧化,保护心血管和肝脏等,广泛应用于美容、保健、食品和医疗产业。黄杉素目前主要通过植物提取,产量不足限制了其广泛应用,而生物合成方法研究的快速发展有望为其高效获取提供新契机。本文综述了黄杉素的结构性质、生物合成途径、药理作用以及生产方式,并对未来合成生物学技术在黄杉素生产中的应用进行展望。Taxifolin,an active natural dihydroflavonol,exhibits a range of notable pharmacological activities,including antioxidant properties and cardiovascular and hepatic protection effects.Widely utilized in the cosmetic,health,food,and medical industries,taxifolin plays a crucial role in the treatment of liver and cardiovascular diseases.While traditionally extracted from plants,limited yields hinder its widespread application.Recent advancements in biosynthetic methods present new opportunities for efficient production.This review delves into the structural characteristics,biosynthetic pathways,pharmacological effects,and production techniques of taxifolin,while also exploring the potential integration of synthetic biology technologies to enhance taxifolin production in the future.

关 键 词：黄杉素 生物合成途径 药理作用 生产工艺 

分 类 号：R28[医药卫生—中药学]