依托咪酯检测方法、毒性损害及滥用的研究进展  

Research Progress of Etomidate in Analyzing Methods,Toxic Damage and Abuse Situation

作　　者：苏秦 杨成梁 何美云 赵枢泉 刘卫国 赵虎[4,5] 刘超 SU Qin;YANG Chengliang;HE Meiyun;ZHAO Shuquan;LIU Weiguo;ZHAO Hu;LIU Chao(National Anti-Drug Laboratory Guangdong Regional Center,Guangzhou 510230,China;Anti-Drug Technology Center of Guangdong Province,Guangzhou 510230,China;School of Forensic Medicine,Southern Medical University,Guangzhou 510515,China;Department of Forensic Medicine,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou 510080,China;Guangdong Province Translational Forensic Medicine Engineering Technology Research Center,Guangzhou 510080,China)

机构地区：[1]国家毒品实验室广东分中心,广东广州510230 [2]广东省毒品实验技术中心,广东广州510230 [3]南方医科大学法医学院,广东广州510515 [4]中山大学中山医学院法医学系,广东广州510080 [5]广东省法医学转化医学工程技术研究中心,广东广州510080

出　　处：《中国司法鉴定》2024年第2期55-60,共6页Chinese Journal of Forensic Sciences

基　　金：公安部技术研究计划项目(2022JSM02)。

摘　　要：依托咪酯作为短效麻醉药在临床应用中广受认可,但在包括中国在内的一些国家却存在依托咪酯的滥用和误用问题,严重者则导致死亡。目前,中国已将依托咪酯列为第二类精神药品,具备毒品性质。非法滥用依托咪酯可能导致多器官系统的严重危害,包括内分泌、神经和心血管系统等。通过探讨依托咪酯滥用的毒性机制、毒性损害、代谢分布和检测方法,为其滥用监管和鉴定评价提供参考。Although the clinical use of etomidate is widely recognized,there are issues of abuse and misuse of etomidate leading to fatalities,in some countries including China.Currently,China has classified etomidate as a second-class psychoactive drug with narcotic properties.Illicit use of etomidate can result in severe harm to multiple organ systems,including endocrine,nervous,and cardiovascular systems.By exploring the toxic mechanism,toxic damage,metabolic distribution,and analyzing methods of etomidate abuse,this paper provides a reference for the regulatory control and forensic evaluation of etomidate abuse.

关 键 词：依托咪酯 色谱技术 毒性损害 滥用 监管 

分 类 号：DF795.1[医药卫生—法医学]