苯巴比妥钠联合地西泮治疗热性惊厥患儿的效果  

Effects of Phenobarbital sodium combined with Diazepam in treatment of children with febrile convulsion

作　　者：马群芳 MA Qunfang(Department of Pediatrics of Henan Tianyou Integrated Traditional Chinese and Western Medicine Tumor Hospital,Zhengzhou 451100 Henan,China)

机构地区：[1]河南天佑中西医结合肿瘤医院儿科,河南郑州451100

出　　处：《中国民康医学》2024年第10期86-88,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察苯巴比妥钠联合地西泮治疗热性惊厥患儿的效果。方法:回顾性分析2020年9月至2021年9月该院收治的90例热性惊厥患儿的临床资料,按照不同治疗方法分为观察组和对照组各45例。对照组采用地西泮治疗,观察组在对照组基础上联合苯巴比妥钠治疗,比较两组临床疗效、住院时间、惊厥症状控制时间、体温恢复正常时间、血清脑神经相关因子[中枢神经特异性蛋白(S100β)、神经元特异性烯醇化酶(NSE)、脑神经营养因子(BDNF)]水平和不良反应发生率。结果:观察组治疗总有效率为95.56%,明显高于对照组的75.56%,差异有统计学意义(P<0.05);观察组住院时间、惊厥症状控制时间、体温恢复正常时间均短于对照组,差异有统计学意义(P<0.05);治疗3 d后,两组血清S100β、NSE、BDNF水平低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:苯巴比妥钠联合地西泮治疗热性惊厥患儿可提高治疗总有效率,缩短住院时间、惊厥症状控制时间和体温恢复正常时间,以及降低血清脑神经相关因子水平,效果优于单纯地西泮治疗。Objective:To observe effects of Phenobarbital sodium combined with Diazepam in treatment of children with febrile convulsion.Methods:The clinical data of 90 children with febrile convulsion admitted to this hospital from September 2020 to September 2021 were retrospectively analyzed.According to different treatment methods,they were divided into observation group and control group,45 cases in each group.The control group was treated with Diazepam,while the observation group was treated with Phenobarbital sodium on the basis of that of the control group.The clinical efficacy,the hospitalization time,the convulsion symptom control time,the body temperature recovery time,the serum cranial nerve-related factors[central nervous system specific protein(S100β),neuron-specific enolase(NSE),brain neurotrophic factor(BDNF)]levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.56%,which was significantly higher than 75.56%of the control group,and the difference was statistically significant(P<0.05).The hospitalization time,the convulsion symptom control time and the body temperature recovery time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After 3 days of treatment,the levels of serum S100β,NSE and BDNF in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Phenobarbital sodium combined with Diazepam in the treatment of the children with febrile convulsion can improve the total effective rate of treatment,shorten the hospitalization time,the convulsion symptom control time and the body temperature recovery time,and reduce the levels of serum cranial nerve related factors.Moreover,it is s

关 键 词：热性惊厥 苯巴比妥钠 地西泮 住院时间 不良反应 脑神经相关因子 

分 类 号：R971.6[医药卫生—药品]