地塞米松联合头孢噻肟治疗化脓性脑膜炎患儿的效果  

Effects of Dexamethasone combined with Cefotaxime in treatment of children with purulent meningitis

作　　者：刘敏 LIU Min(Department of Pediatrics of Taiqian County People’s Hospital,Puyang 457600 Henan,China)

机构地区：[1]台前县人民医院儿科,河南濮阳457600

出　　处：《中国民康医学》2024年第10期89-91,95,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察地塞米松联合头孢噻肟治疗化脓性脑膜炎(PM)患儿的效果。方法:回顾性分析2021年9月至2023年9月该院收治的94例PM患儿的临床资料,按照不同治疗方案分为观察组(n=47)和对照组(n=47)。对照组予以头孢噻肟治疗,观察组在对照组基础上联合地塞米松治疗,比较两组临床疗效、脑脊液指标(白细胞计数、蛋白质浓度、葡萄糖浓度)水平、血清因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-12(IL-12)、淀粉样蛋白(SAA)、基质金属蛋白酶-9(MMP-9)、可溶性B7同源体3(sB7-H3)、神经元特异性烯醇化酶(NSE)、中枢神经特异性蛋白(S100β)]水平和不良反应发生率。结果:观察组治疗总有效率为95.74%,明显高于对照组的76.60%,差异有统计学意义(P<0.05);治疗后,两组脑脊液白细胞计数、蛋白质浓度和血清NSE、S100β、MMP-9、sB7-H3、TNF-α、SAA、IL-12水平低于治疗前,且观察组低于对照组,两组脑脊液葡萄糖浓度高于治疗前,且观察组高于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:地塞米松联合头孢噻肟治疗化脓性脑膜炎患儿可提高治疗总有效率,改善脑脊液指标水平,降低血清因子水平,效果优于单纯头孢噻肟治疗。Objective:To observe effects of Dexamethasone combined with Cefotaxime in treatment of children with purulent meningitis(PM).Methods:The clinical data of 94 children with PM admitted to this hospital from September 2021 to September 2023 were retrospectively analyzed.According to different treatment options,they were divided into observation group(n=47)and control group(n=47).The control group was treated with Cefotaxime,while the observation group was treated with Dexamethasone on the basis of that of the control group.The clinical efficacy,the cerebrospinal fluid indexes(white blood cell count,protein concentration,glucose concentration)levels,the serum factors[tumor necrosis factor-α(TNF-α),interleukin-12(IL-12),amyloid protein(SAA),matrix metalloproteinase-9(MMP-9),soluble B7 homolog 3(sB7-H3),neuron-specific enolase(NSE),central nervous system specific protein(S100β)]levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.74%,which was significantly higher than 76.60%of the control group,and the difference was statistically significant(P<0.05).After the treatment,the cerebrospinal fluid white blood cell count,protein concentration and the serum NSE,S100β,MMP-9,sB7-H3,TNF-α,SAA and IL-12 levels in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;the cerebrospinal fluid glucose concentration of the two groups was higher than that before the treatment,and that of the observation group was higher than that of the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Dexamethasone combined with Cefotaxime in the treatment of the children with purulent meningitis can improve the total effective rate of treatment,improve the levels of cerebrospinal fluid indexes,and reduce the levels of serum

关 键 词：头孢噻肟 地塞米松 化脓性脑膜炎 脑脊液 血清因子 不良反应 

分 类 号：R512.3[医药卫生—内科学]