经重组人碱性成纤维细胞因子处理人工真皮在上肢深度烧伤创面修复中的应用  

Application effects of rh-bFGF treated artificial dermis in the repair of deep burn wounds in the upper limb

作　　者：戴如冰 童海东[1] 赵轶君[1] Dai Rubing;Tong Haidong;Zhao Yijun(Department of Burn and Plastic Surgery,China Coast Guard Hospital of the People′s Armed Police Force,Jiaxing,Zhejiang 314000,China)

机构地区：[1]中国人民武装警察部队海警总队医院外三(烧伤整形)科,浙江嘉兴314000

出　　处：《中国药物与临床》2024年第6期395-399,共5页Chinese Remedies & Clinics

摘　　要：目的探讨采用重组人碱性成纤维细胞因子(rh-bFGF)处理的人工真皮在上肢深度烧伤创面治疗中的应用效果和安全性。方法回顾性分析中国人民武装警察部队海警总队医院在2021年2月至2023年2月收治的行人工真皮移植治疗的54例上肢深度烧伤患者的临床资料。其中25例患者的人工真皮经0.9%氯化钠注射液处理(对照组),余29例患者的人工真皮经rh-bFGF溶液处理(观察组)。比较2组植皮间隔时间、创面愈合周期、植皮存活率、临床疗效、并发症以及治疗前后Quick上肢功能(Quick-DASH)评分和温哥华瘢痕量表(VSS)评分。结果观察组植皮间隔时间(8.6±1.8)d和创面愈合时间(9.3±3.3)d均低于对照组[(12.9±2.8)d、(14.7±4.8)d](P<0.05)。观察组治疗总有效率高于对照组(97%与76%,P<0.05)。观察组治疗后3个月和6个月时的Quick-DASH评分和VSS评分均低于对照组(P<0.05)。观察组和对照组植皮存活率比较差异无统计学意义(97%与80%,P>0.05)。结论rh-bFGF处理人工真皮能够缩短上肢深度烧伤创面植皮和创面愈合时间,提高临床疗效,改善患者瘢痕增生功能和上肢功能。Objective To explore the application effects and safety of artificial dermis treated with recombinant human basic fibroblast growth factor(rh-bFGF)in the treatment of deep burn wounds in the upper limb.Methods A retrospective analysis was conducted on the clinical data of 54 patients with deep upper limb burns treated with artificial dermal transplantation in China Coast Guard Hospital of the People′s Armed Police Force from February 2021 to February 2023.Among them,25 patients had their artificial dermis treated with physiological saline(control group),while the other 29 patients had their artificial dermis treated with rh-bFGF solution(observation group).The graft interval time,wound healing time,graft survival rate,clinical efficacy,complications,as well as the Quick upper limb function(Quick DASH)score and Vancouver Scar Scale(VSS)score before and after treatment were compared between the two groups.Results The interval time between skin grafting[(8.6±1.8)d and wound healing time(9.3±3.3)d]in the observation group were significantly shorter than those in the control group[(12.9±2.8)d;(14.7±4.8)d](P<0.05).The total effective rate of the observation group was significantly higher than that of the control group(97%vs.76%,P<0.05).The Quick-DASH score and VSS score of the observation group were significantly lower than those of the control group at 3 and 6 months after treatment(P<0.05).There was no significant difference in the survival rate of skin grafting(97%vs.80%)between the two groups(P>0.05).Conclusion The artificial dermis treated with rh-bFGF can shorten the grafting and healing time of deep burn wounds in the upper limbs,improve clinical efficacy,and improve scar hyperplasia and upper limb function in patients.

关 键 词：烧伤 重组人碱性成纤维细胞因子 真皮 创面 上肢 

分 类 号：R644[医药卫生—外科学]